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Method of Analysis for Sodium Hydroxide


Procedure for analysis for Sodium Hydroxide in pharmaceutical quality control laboratory.
1. Description
White, crystalline masses supplied as sticks, pellets or slabs; deliquescent.

2. Solubility
Very soluble in water; freely soluble in ethanol (95%).

3. Assay
Limit: NLT 97.0 % & NMT 100.5 %.
Reagent required
Phenolphthalein
Methyl orange
1M Hydrochloric acid
Procedure
Weigh accurately about 2 g, dissolve in about 80 ml of carbon dioxide-free water, add 0.3 ml of phenolphthalein solution and titrate with 1M hydrochloric acid. Add 0.3 ml of methyl orange solution and continue the titration with 1M hydrochloric acid. Each ml of 1M hydrochloric acid used in the second part of the titration is equivalent to 0.1060 g of Na2CO3. Each ml of 1M hydrochloric acid used in the combined titrations is equivalent to 0.0400 g of total alkali, calculated as NaOH.
Calculation:

                                                  Total B.R. X Molarity X 0.04X100
% of Sodium Hydroxide = ------------------------------------------
                                                           Wt. Taken in gm X 1.0



Ankur Choudhary is India's first professional pharmaceutical blogger, author and founder of Pharmaceutical Guidelines, a widely-read pharmaceutical blog since 2008. Sign-up for the free email updates for your daily dose of pharmaceutical tips.
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