1. Switch ‘ON”
the power, instrument will initialize.
2. Press the
RPM, TEMP, TIME, and OPTN keys from the front panel to set the parameters of
the test.
3. Change
protocol no. using Increment / Decrement keys.
4. Press the
ENTER key to register the set parameter in the protocol, such 20 protocols can
be prepared.
RPM Setting:
1. Press the
RPM key from the front panel. Set the RPM from 25 to 200 using the
UP / DOWN / DIGIT SCROLL key as per requirement.
2. To start or
stop the stirrer use F1 or F2 keys respectively.
Temperature Setting:
1. Press the
TEMP key from the front panel. Set the temperature from 30.0°C to 40.0°C by
using UP / DOWN / DIGIT SCROLL key.
2. Switch heater ON/OFF BY using the function
key F1/F2 Press ENTER key to register the change.
3. “TEMP ON”
LED on the front panel will glow after switching on heater. The pump and
the Heater ON LED on temperature Controller Unit ETC-11L will glow.
Sample Interval Setting:
1. Press the
TIME key from the front panel to display the screen for setting the Sample
Interval Time.
2. Maximum 12
Samples Interval and the Sample Time can be set from 00 Min. to 23 Hrs, 59
Min. Set using UP / DOWN / DIGIT SCROLL key.
3. Press the
ENTER key to register the value.
NOTE – If the SAMP. INTV. is kept to 00 Min. then that
particular step will be skipped.
Parameter setting from OPTN key:
1. Set Bath Set
Up, Sampler Set Up, Sampler Calibration, Print Set Up, Clock, Date, Wakeup
Time, Circulating Pump, Temperature Control, and Power Fail delay, Cleaning
Cycle etc. by using the OPTN key from the front panel.
2. Use Function
key F1 (for NEXT) and F2 (for PREVIOUS) to scroll the parameters.
3. Press enter
key to change the selected parameter.
4. Enter
changes press enter key to register the changes made. NOTE – In case of filters
to be immersed the filter will be at the top level of the media to avoid
Hydrodynamic problem.
5. Use UP /
DOWN keys and DIGIT SCROLL key to choose the test method as Paddle or
Basket. Select method by using the UP / DOWN key. Press ENTER key
to register the settings.
6. Press the
scroll key to enable to select the filters to be immersed or remain out side
the media pressing the ENTER key will register and OPTN screen will be
displayed again. Use scroll UP or DOWN through the options using the
Function keys F1 or F2 respectively.
Wakeup Time Setting:
1. Press the F1
key to select the option for the Wakeup Time Setting.
2. Press the
ENTER key to display the screen for the Wakeup time setting.
3. Set time and
the date feature by using UP / DOWN & DIGIT SCROLL keys.
4. Keep sleep
Mode ON using the Function key F1.
5. Keep main
power supply on during wakeup mode, the backlight will be Off, it start
operating at set wakeup time and date.
Circulating Pump Setting:
1.
Press the F1 key to select the option
for the Circulating Pump setting.
2. Press the ENTER key to display the screen for
the Circulating Pump setting.
3. The pump can be set ON / OFF using the
function key F1 or F2 respectively.
4. Press the ENTER key to register the value and
the OPTN screen will be displayed again.
5. Scroll UP or DOWN through the options using
the function keys F1 or F2 respectively.
6. Set the test parameters as required.
7. Insert the paddle / Basket rod.
Procedure for USP apparatus I method (basket):
1.
Check that set temperature is reached.
NOTE
– When USP Apparatus I method (Basket) is used, place the test sample inside
the basket and then insert the basket rod and lower the instrument by pressing
Lift DOWN key provided on the Front Panel of TDT-08L.
2. Do not hold the basket on the mesh.
3. Hold the baskets at the ring of the open end
and gently secure the basket is fully inserted on the basket holder.
4. Make sure that the basket is fully inserted
on the basket holder.
Procedure for USP apparatus II method (paddle):
1. Insert the Paddle.
2. Lower the paddle by pressing Lift DOWN key
provided on the Front Panel.
3. Drop the test Sample in test vessel after
reaching set temperature.
4. Press the START key from the front panel to
start the test after reaching set temperature. The instrument will now
show the Run Time Screen.
5. Check the Run Time Screen for the Protocol
no., The Step No., The Elapsed Sampling time for the particular Step, actual
RPM of stirrer, actual Bath Temperature and the temperature being measured by
the external probe.
6. The RUN LED on the Front Panel will glow
indicating the Instrument RUN Condition.
7. Check that paddle/basket are properly
lowered, if instrument will prompt an error screen as lift is not at lower
position and hence the test cannot start.
8. Check that temperature is reached at set
temperature, If instrument will prompt an error screen stating the temperature
has not yet reached and hence the test cannot start.
Resetting the Instrument:
1. To RESET the instrument in Run condition,
press the RESET Switch provided on the rear Right Hand Side. The Test
will abort.
Halting / Aborting Test:
1. To halt the running test, press the STOP key
once. The test will be Halted and the Halt Time will be displayed.
The HALT LED on the Front Panel will start blinking.
2. Start the test by pressing F1, then the test
will start from the point it has stopped and the Halt Time is not accounted.
The instrument will display the Run Screen again.
3. Stop the test by pressing F2 key, then the
test will be aborted and the instrument will show the idle screen.
Power Fail Condition:
1. During test running time, if the Power fails
then the Power Failure screen will be displayed when the power is resumed back.
2. The user can either start the test again or
can stop the test by pressing the F1 or F2 key respectively.
3. If the F1 key is pressed, then the test will
start from the point it has stopped and the instrument will display the Run
Screen again.
Sample Withdraw Procedure:
Withdraw
sample from a zone midway between the surface of the dissolution medium
and top of rotating basket/paddle,
not less than 10 mm from wall of vessel.
Dissolution Medium Preparation:
Prepare
the dissolution medium as per specified under monograph or procedure, filter
through 0.45 mm filter paper
under vacuum and stirring.
Note: Replace
the water from the bath weekly or early if required.
