1.0 OBJECTIVETo lay down procedure for cleaning.
2.0 SCOPEThis procedure is applicable to all dissolution test apparatus, installed in quality control laboratory
3.0 RESPONSIBILITY3.1 Doing : Worker
3.2 Checking : Executive/Manager
4.0 ACCOUNTABILITYHead of the Department
5.0 PROCEDURE5.1 Raise the motor driven to upper side by Up/Stop/Down switch.
5.2 Switch ‘OFF’ the instrument.
5.3 Switch ‘OFF’ the Main.
5.4 Cleaning procedure for Apparatus
Frequency: After completion of every dissolution test.
5.4.1 Remove the bowl from its place discard the medium of bowl and wash the each bowl properly with purified water then keep inside the dissolution bath number wise.
5.4.2 Remove the baskets from Basket apparatus and then basket/paddle from the dissolution test apparatus with the help of key. Wash them with purified water, dry with tissue paper and keep at proper place.
5.4.3 Keep the record in the instrument log card.
5.5 Cleaning procedure for water bath of dissolution test apparatus.
Frequency : Once in a week or whenever necessary
5.5.1 Remove all the bowls from water bath and the apparatus.
5.5.2 Remove the lid of water bath and discard all the water from the water bath.
5.5.3 Wash the bath with raw water, detergent solution and with raw water sequentially until no foam of detergent remain in the bath. After complete removal of the detergent wash the bath finally with purified water.
5.5.4 Keep the bath to its the original place and clean the dissolution apparatus.
5.5.5 Record it as per Annexure.
5.5.6 Put the lid of water bath and fill bowls with medium in the apparatus. Fill the bath with purified water up to level mark.
6.0 ABBREEVIATIONS6.1 SOP - Standard Operating Procedure
Ankur Choudhary is India's first professional pharmaceutical blogger, author and founder of Pharmaceutical Guidelines, a widely-read pharmaceutical blog since 2008. Sign-up for the free email updates for your daily dose of pharmaceutical tips.
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