SOP for Calibration of pH Meter Temperature Sensor : Pharmaceutical Guidelines

SOP for Calibration of pH Meter Temperature Sensor

Standard operating procedure for the calibration of pH meter temperature sensor using water for injection (WFI) / purified water (PW).

1.0  Objective 

       To provide a standard operating procedure for the calibration of pH meter temperature sensor. 

2.0  SCOPE

       This procedure is applicable to  pH meter.   

3.0  Responsibility

3.1  Doing      : Technical Assistant/Executive
3.2  Checking : Executive /Manager 

4.0  Accountability

       Head of the Department

5.0  Procedure

       Frequency  :Twice in Year.

5.1  Calibration Procedure for pH meter temperature sensor

5.1.1  Keep the sensor probe of reference calibrated digital thermometer in the beaker containing water for injection (WFI) / purified water (PW) of about temperature 35°C.
5.1.2  Add cold WFI/PW slowly drop wise and bring the temp. between 27°C to 30°C.
5.1.3  Compare the temp. shown by reference calibrated digital thermometer and pH meter & record it in format as Annx. I.
5.1.4  Add WFI/PW in some more quantity slowly drop wise to bring the temp. between 26°C to 23°C.
5.1.5  Compare the temp. shown by reference calibrated digital thermometer and pH meter & record it in format as Annx. I.
5.1.6  Add cold WFI/PW slowly drop wise and bring the temp. between 20°C to 22°C.
5.1.7  Compare the temp. shown by reference calibrated digital thermometer and pH meter & record it in format as Annx. I.

5.1.8  Acceptance Criteria : ± 3°C

6.0  Abbreviations

6.1  oC= Degree centigrade


                                                                    ANNEXURE-I

Q. C. Department
PH METER TEMPERATURE SENSOR RECORDS
                                                                   
REF.No.         :_________________
                                                               ISSUE DATE: _________________
                                                                  ISSUED BY :____________________   




Calibrated  Ref. Digital Thermometer No.:____________________ 
Ref. Thermometer Calibration date          :____________________
Ref. Thermometer Certificate No.            :____________________
Ref. Thermometer Calibration Due Date  : ____________________
pH meter ID.No.                                      : ___________________
Results Observed:
Set Range
Observation
Difference
tolerance
Temperature as read on pH meter
Temperature as on read on display of Ref. Thermo.
30°C to 27°C



±0.3°C
26°C to 23°C



22°C to 20°C




Remarks                 :
Calibration date          :
Next Calibration date  :
Calibrated  by             :
Checked by                 :



Ankur Choudhary is India's first professional pharmaceutical blogger, author and founder of Pharmaceutical Guidelines, a widely-read pharmaceutical blog since 2008. Sign-up for the free email updates for your daily dose of pharmaceutical tips.
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