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Different Stages of Tablet Manufacturing Process

The tablet manufacturing process is a critical step in the production of pharmaceuticals. Tablets are a solid dosage form that is taken orally.
In this article, we will be discussing the different stages of the tablet manufacturing process. This process is essential in ensuring that the right drug or ingredient is delivered to the patient in the right dosage form. By understanding the various steps involved in tablet manufacturing, pharmaceutical companies can ensure a higher quality product and avoid any potential errors.

Tablet Manufacturing Process

The tablet manufacturing process is a critical step in the production of pharmaceuticals. Tablets are a solid dosage form of medication that is taken orally. They are made by combining active ingredients with excipients, which are inactive materials that help to bind, fill, and lubricate the tablet. The process of making tablets involves several steps, including granulation, compression, and coating.

Granulation is the first step in the tablet manufacturing process. This is where the active ingredients and excipients are combined and ground into a fine powder. The powder is then passed through a sieve to remove any large particles.

Compression is the next step in the tablet manufacturing process. The powder from the granulation step is placed into a die, which is a metal mold with a cavity in the shape of the desired tablet. The die is then placed into a tablet press, which uses extreme pressure to compress the powder into the die cavity.

The coating is the final step in the tablet manufacturing process. The compressed tablets from the previous step are coated with a thin layer of film to protect them from moisture and degradation.


The process of granulation is an important step in the tablet manufacturing process. Granulation is the process of breaking down a powder into smaller particles. This is done in order to make it easier to compress the powder into tablets. There are two main types of granulation: wet granulation and dry granulation. Wet granulation involves adding a liquid to the powder and then breaking it down into smaller particles. Dry granulation involves breaking down the powder into smaller particles without adding any liquid.

Granulation is typically done using specialized equipment, such as a granulator. Granulators come in a variety of types, but all operate on the same principle. The powder is added to the granulator and then broken down into smaller particles. The size of the particles can be controlled by adjusting the settings on the granulator.


Blending is the process of mixing together all of the ingredients that will be used in the tablet. This includes both active and inactive ingredients. The goal of blending is to create a homogeneous mixture that is uniform in composition.

Blending can be done either manually or using specialized equipment. Manual blending is typically only done on a small scale, while large-scale operations will use industrial blenders. Blenders come in a variety of types, but all operate on the same principle. Ingredients are added to the blender in a specified order and then mixed together until a uniform mixture is achieved.

The process of blending is important because it ensures that all ingredients are evenly distributed throughout the tablet. This is critical to ensuring that the tablet dissolves evenly and releases its active ingredients correctly when taken by a patient.


Drying is the process of removing moisture from material. In the pharmaceutical industry, drying is often used to remove water or solvents from a product prior to packaging. There are several methods that can be used to dry pharmaceutical products but generally, a fluid bed dryer (FBD) is used for drying.

A fluid bed dryer is a type of drying equipment that uses hot air to dry material. The material is placed on a perforated plate and hot air is passed through it. The hot air evaporates the moisture from the material and the dried product is collected on the other side of the perforated plate. It is important to ensure that the material is completely dry before compression for desired moisture.


The tablet compression process is the stage of tablet manufacturing where the powder or granules are compressed into the desired shape. This is done using a tablet press, which exerts a high amount of force on the powder to compress it into the die of the tablet press. The tablet press can have one or more dies, which determines the shape and size of the tablet.

Compression is an important step in tablet manufacturing because it affects the physical properties of the tablet, such as its hardness, friability, and density. The compression process also affects the way the tablet dissolves and how much active ingredient is released when it dissolves. Tablet presses can be programmed to apply different levels of force to the powder, which affects these physical properties.


There are different stages of the tablet manufacturing process in pharmaceuticals. One stage is coating. Tablet coating provides many benefits, including:
  • Improved appearance
  • Improved stability
  • Reduced bitter taste
  • Reduced dissolution rate
  • Masking unpleasant tastes
There are several methods that can be used to apply coatings to tablets. The most common methods are spraying and dipping. Spraying involves using a spray gun to apply the coating material to the tablet. Dipping involves immersing the tablet in a coating material and then removing it.

Both of these methods require the use of specialized equipment. Spraying requires a spray gun and a drying oven, while dipping requires a coating pan and a drying oven. The type of equipment that is used will depend on the type of coating material that is being applied.

The coating process is typically done on a large scale using industrial equipment. However, smaller-scale operations may use manual methods, such as brushing or spraying the coating material onto the tablet by hand.

Polishing and Printing

After the tablet has been formed and dried, it needs to be polished. This is done to give the tablet a smooth surface and to remove any sharp edges. The tablet is then printed with the desired information which is called tablet branding.

Quality Control and Packing

In the final stage of tablet manufacturing, quality control (QC) and packing teams work together to ensure that the finished product meets all required standards before it is shipped out. QC inspectors conduct a series of tests on each batch of tablets to check for things like potency, appearance, and disintegration time. Once the tablets pass QC, they are transferred to the packing area where they are packaged according to customer specifications.


The process of tablet manufacturing in pharmaceuticals can be divided into several stages. These include granulation, compression, coating, and packaging. Each stage is important in the overall process and requires specialized equipment and knowledge. By understanding the different stages of tablet manufacturing, pharmaceutical companies can ensure that their products meet the highest standards of quality and safety.

Ankur Choudhary is India's first professional pharmaceutical blogger, author and founder of Pharmaceutical Guidelines, a widely-read pharmaceutical blog since 2008. Sign-up for the free email updates for your daily dose of pharmaceutical tips.
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