Determination of Solubility in Pharmaceuticals | Pharmaguideline
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  • Jun 12, 2011

    Determination of Solubility in Pharmaceuticals

    Learn how to determine the Solubility of Pharmaceutical ingredients.
    NOTE: A test for solubility becomes a test for purity only where a special quantitative test is given in the individual monograph and is an official requirement.

    The approximate solubility of the articles of the Pharmacopoeia are given here primarily as information; they are not meant to be applied as tests for identifying materials. However, they may indirectly help in the preliminary evaluation of the integrity of an article. They have been indicated by descriptive terms in the accompanying table and have the following significance with reference to a temperature of 15°C to 30°C.

    Descriptive Item (gm)
    Parts of Solvent required for Part of Solute (ml)
    Very soluble
    Less than 1
    Freely soluble
    From 1 to 10
    Soluble
    From 10 to 30
    Sparingly soluble
    From 30 to 100
    Slightly soluble
    From 100 to 1000
    Very slightly soluble
    From 1000 to 10,000
    Practically insoluble or Insoluble
    10,000 or more

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