SOP for Cleaning of Vacuum Oven

Standard operating procedure to clean the vacuum oven used for determination of LOD.

1.0 OBJECTIVE

To clearly lay down the procedure for cleaning.

2.0 SCOPE

This procedure is applicable for vacuum oven installed at, quality control laboratory.

3.0 RESPONSIBILITY

3.1 Doing: Technical Assistant
3.2 Checking: Executive/Manager

4.0 ACCOUNTABILITY

Head of the Department

5.0 PROCEDURE

5.1 After completion of the testing, switch ‘OFF ’ the instrument.
5.2 Release the vacuum carefully and slowly with pressure regulator till zero pressure observed in pressure gauge.
5.3 Allow the oven to cool down to room temperature.
5.4 Loose the screw door carefully and open the door, take out the LOD bottles and put into desiccator.
5.5 Remove any solid or unlabeled waste items from the oven.
5.6 Remove the self from the oven and clean with a cotton cloth
5.7 Clean the inner surface of the oven with a clean dry cloth.
5.8 Keep the self into its respective place.
5.9 Switch on the instrument and set the temperature as per operating procedure

6.0 ABBREVIATIONS

6.1 SOP - Standard Operating Procedure
6.2 LOD - Loss on drying
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is a prominent Pharmaceutical Quality Assurance expert, consultant and the founder of Pharmaguideline. With over 22 years of hands-on experience in cGMP-compliant manufacturing environments, he specializes in establishing validation protocols, sterile area controls and data integrity systems. Ankur routinely interprets international regulatory frameworks (including FDA, EMA and ICH guidelines) to help global pharmaceutical professionals ensure strict regulatory compliance and operational excellence. Connect with Ankur on LinkedIn. Need Help: Ask Question

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