Preparation and Standardization of 0.1 M Zinc Chloride : Pharmaceutical Guidelines

Preparation and Standardization of 0.1 M Zinc Chloride

Preparation and standardisation of the 0.1 M Zinc Chloride using Disodium Edetate solution and Xylenol orange mixture as indicator used for pharmaceutical analysis.

Zinc Chloride Solution Preparation:

• Add about 6.6 gm of granulated zinc (previously washed with 0.1M HCl and then water) and dissolve in a minimum amount of 2 M HCl.
• Add more about 700 ml of purified water, mix and allow to cool to room temperature.
• Make up the volume 1000 ml with purified water. Mix solution thoroughly.
• Keep the solution for at least an hour and than carryout the standardization.

Zinc Chloride Solution Standardization:

Method I

• Take 25 ml of 0.1 M Zinc chloride solutions into a clean & dried conical flask.
• Add about 4 gm ammonium acetate.
• Add 25 ml distilled water and add about 50 mg xylenol orange mixture. shake well.
• Add sufficient hexamine.
• Titrate the above solution with standardized 0.1 M Disodium Edetate with constant stirring and until the solution gives yellow color.
• Note down the burette reading.

                                                         Molarity of EDTA x Burette Reading
Molarity of 0.1 M Zinc chloride = -----------------------------------------------------

Method II

•  To 25.0 ml of the solution add 4 g of ammonium acetate and 25 ml of water. 
•  Add 50 mg of xylenol orange mixture and sufficient hexamine, and titrate with 0.1 M disodium edentate until the colour changes to yellow.
•  1 ml of 0.1 M disodium edetate is equivalent to 0.013630 g of ZnCl2.

Also see: Determination of Shelf Life of Solutions in Laboratory

Ankur Choudhary is India's first professional pharmaceutical blogger, author and founder of Pharmaceutical Guidelines, a widely-read pharmaceutical blog since 2008. Sign-up for the free email updates for your daily dose of pharmaceutical tips.
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