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Pharmaceutical Guidelines

C18 HPLC Columns and Their Properties

Standards and success of any pharmaceutical company is determined by how professional chemical analysis are being undertaken. Chromatography remains the most important technique for identifying and analyzing a wide variety of chemical samples within pharmaceutical industries. The technique does not…

Mechanism of Separation of Components by HPLC

HPLC stands for High Performance Liquid Chromatography. This is an analytical chemistry technique that is used to separate, quantify and identify every component that is in a mixture. The technique depends on pumps to push some constrain liquid solvent which contains a mixture of the sample through…

Difference between C8 and C18 Columns Used in HPLC System

High Performance Liquid Chromatography (HPLC) refers to a technique in analytical chemistry that is used to identify, separate and quantify each component in a mixture. C8 and C18 both refer to the alkyl chain of a bonded face of a column. They are both used in the high performance liquid chromatog…

Differences between HPLC and UPLC

Liquid chromatography is a technique that is utilized to separate any sample into its individual components. In this case, the chromatographic procedure involves a liquid as the moving phase. HPLC and UPLC stand for High Performance Liquid Chromatography and Ultra Performance Liquid Chromatography …

Karl Fischer Reagent and Its Reactions

You are given a sample with a trace amount of water and you need to determine the amount of water in the sample, what do you do? The method to use is the Karl Fischer (KF) moisture analysis. Karl Fischer method uses the Karl Fischer Reagents to determine the moisture content of a sample and it is a…

Electronic Batch Records in Pharmaceuticals

Traditionally, most pharmaceutical companies used hard copy records to keep production batch records commonly known as master production batch records. However, this documentation method has numerous shortcomings. In 1997, Electronic Batch records in Pharmaceuticals were accepted by FDA after EBR …

Validation of Clean Room Pass Boxes

A pass box which is also called a hatch is an equipment which is used to transfer pharmaceutical material from an area of lower cleanliness to an area of higher cleanliness and vise-versa. They, therefore, work as a barrier between areas with different levels of cleanliness.

Occupational Exposure Bands (OEBs) for Chemicals

Occupational exposure bands are measures put in place to categorize chemicals so that the health of the worker is not compromised. This is because Active Pharmaceutical Ingredients can have serious and adverse effects on the worker when they become lowly airborne. They are usually classified on th…

Reynolds Number and Its Significance in Purified Water System

Purified water is commonly used in the pharmaceutical industry, science laboratories, laser cutting and automotive use. Purified water finds a considerable amount of usage in the pharmaceutical industry in the form of a raw material, component and solvent in the production of a number of medicatio…

Types of Primary Packaging in Pharmaceuticals

Packaging is one of the most important parts of the pharmaceutical industry. The packaging ensures the protection of drug during the sale, storage, and use. Objectives of packaging are containment, physical and chemical protection, portion control, and security of the drug. Packaging in the pharma…

Site Acceptance Test (SAT)

Site Acceptance Test can determine whether or not systems are meeting the desired and required specifications. The main purpose of site acceptance testing is to give an overall evaluation of a systems compliance and to ensure this compliance meets the requirements of the business involved. Site ac…

Packaging of Pharmaceutical Products

In the healthcare field, pharmaceutical packaging plays a vital role in keeping prescribed drugs and medication safe from all sorts of contamination and bacterial growth. Unlike other goods, pharmaceutical medicines require a much thorough inspection of their packaging so that they are completely …

Factory Acceptance Test - FAT

Any equipment that is being intended to be used in producing various products has to meet certain specifications before it is delivered to a purchaser and installed. The equipment has to undergo what is called Factory Acceptance Test (FAT) so as to ensure its proven quality and compliance. These t…

Top 10 Tips for Microbial Limit Test

The microbial limit test is the quantitative and qualitative assessment of the microbes or microbial contamination test in a sample. This test is performed for:- estimation of the total viable count of fungi and bacteria i.e. Quantitative estimation. Identification of each of the microbes of impor…

Causes and Remedies of Binding in Tablet Manufacturing

Tablet manufacturing involves a series of processes all aimed at the result of a uniform fine piece of art tablet. This article aims at exploring the causes and remedies of binding in tablet manufacturing. The processes include sizing, milling, drying, and compressing among several other procedure…

Differences between Syrups and Suspensions

Do you know that all pharmaceutical syrups are not manufactured equally? If you don’t, then don’t scratch your head. In fact, there is a subtle difference in these products that can cause ineffective use in clinical effects. Pharmaceutical syrup generally can be broken down into different categori…

About the Author




Ankur Choudhary is experienced in pharmaceutical, author and founder of Pharmaceutical Guidelines, a widely-read pharmaceutical blog since 2008.
Email: info@pharmaguideline.com

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