SOP for De-aeration of Dissolution Media : Pharmaceutical Guidelines

SOP for De-aeration of Dissolution Media

Standard operating procedure to explain the De-aeration of Dissolution Media.

1.0  OBJECTIVE 

       To lay down the procedure for De-aeration of Dissolution media.

2.0  SCOPE 

       This procedure is applicable to dissolution method which specifies the use of De-aerated dissolution medium. 

3.0  RESPONSIBILITY

3.1  Doing      : Technical Assistant
3.2  Checking : Executive/Manager

4.0  ACCOUNTABILITY

       Head of the Department

5.0  PROCEDURE

5.1  Heat the required volume of dissolution medium at about 41°C with gentle stirring .
5.1  Immediately filter the medium with constant stirring under vacuum using a filter, having a porosity of 0.45 micron or less into a suitable filtering flask, equipped with a stirring device.
5.2  Seal the flask with Aluminium foil and continue to apply a vacuum with stirring for an additional five minutes.
5.4  Immediately transfer the medium directly to the dissolution bowl.
5.5  Take precaution to prevent air interruption in medium.

Related: Tablet Dissolution Test in Different Stages (S1, S2 and S3)

6.0  ABBREVIATIONS

6.1  oC = Degree centigrade



Ankur Choudhary is India's first professional pharmaceutical blogger, author and founder of Pharmaceutical Guidelines, a widely-read pharmaceutical blog since 2008. Sign-up for the free email updates for your daily dose of pharmaceutical tips.
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