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SOP for Calibration of Melting Point Apparatus


Standard operating procedure to evaluate the performance of Melting point apparatus.

1.0  OBJECTIVE

       To calibrate the equipment for reliable and accurate results.

2.0  SCOPE

       This procedure is applicable to calibrate the Melting point apparatus, installed in quality control area.

3.0  RESPONSIBILITY 

3.1  Doing       : Technical Assistant / Executive
3.2  Checking  : Executive /Manager

4.0  ACCOUNTABILITY 

       Head of the department.

5.0  PROCEDURE

5.1  Switch “ON” the mains.
5.2  Switch “ON” the instrument.
5.3  Press “menu” key  twice.
5.4  “Recall” will blink.
5.5  Press “enter”.
5.6  Press ‘down’ key till vanillin will blink.
5.7  Press ‘enter’.
5.8  Set point, ‘gradient’ & ‘maximum temperature’ set for vanillin will be displayed.
5.9  Fill vanillin std (previously dried over silica gel for 16 hours.) into the capillary.
5.10  Place the capillary in the heating chamber.
5.11  Press ‘Start’.
5.12  Instrument will beep when set point is reached.
5.13  Press “Start”.
5.14  Note the temperature displayed. 
5.15  Repeat the above step for Phenacetin & Caffeine. (previously dried over silica gel for 16 hours.)
5.16  Press “Stop” to start cooling.
5.17  Press ‘menu’ till the submenu displaying ‘threshold’ is displayed.
5.18  Press ‘menu’ seven times.
5.19  ‘Calibration’ is displayed.
5.20  Enter the password.
5.21  Calibration list is displayed.
5.22  Enter the difference between the rated MP & the observed MP of the 3 Standards.
5.23  Rated MP is displayed on the screen in the calibration menu.
5.24  Press UP to store the calibration.
5.25  Press menu till original menu is displayed.

Related: Melting Range or Temperature (Apparatus and Determination)

6.0  ABBREVIATIONS

6.1  SOP - Standard Operating Procedure




                                           QUALITY CONTROL LABORATORY       
CALIBRATION REPORT OF MELTING POINT APPARATUS

CALIBRATION DATE

DATE OF LAST CALIBRATION DONE
NEXT DUE FOR
CALIBRATION



INSTRUMENT DETAILS

INSTRUMENT NAME

INSTRUMENT MAKE

INSTRUMENT
IDENTIFICATION NO.




OBSERVATION

Sr.No.
Reference Std.
Observed Range
Std. Range
1
Vanillin

81°C – 83°C
2
Phenacetin

134°C – 136°C
3
Caffeine

234°C – 237°C
Ankur Choudhary is India's first professional pharmaceutical blogger, author and founder of Pharmaceutical Guidelines, a widely-read pharmaceutical blog since 2008. Sign-up for the free email updates for your daily dose of pharmaceutical tips.
Email: .moc.enilediugamrahp@ofni Need Help: Ask Question


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