What is Granulation?
Granulation is the process in which powder particles are made to adhere to form agglomerates called granules.
To prevent segregation of the constituents of the mix.
lTo improve the flow properties of the mix.
lTo change the particle size distribution so as to improve the compressibility and to increase apparent density of the powder.
Reasons for granulation are:
lGranulation of toxic material reduce the hazard associated with handling of toxic dust. Granulation should be non-friable & have suitable mechanical strength.
lFor slightly hygroscopic material granulation reduces possibility of caking. As granules can absorb more moisture yet retain their flow ability because of their size.
lGranules being compact than the powder occupy lesser volume per unit weight therefore they are more convenient for storage and shipment.
Bonding mechanisms between particles:
1. Adhesion and cohesion forces in the immobile liquid films between individual primary powder particles.
2. Interfacial forces in mobile liquid films within the granules;
3. The formation of solid bridges after solvent evaporation;
4. Attractive forces between solid particles;
5. Mechanical interlocking.
6. Granulation can improve or modify drug release profile.
Mechanisms of granule formation:
Ankur Choudhary is India's first professional pharmaceutical blogger, author and founder of Pharmaceutical Guidelines, a widely-read pharmaceutical blog since 2008. Sign-up for the free email updates for your daily dose of pharmaceutical tips.
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