Calibration of Automatic Potentiometric Titrator : Pharmaceutical Guidelines

Calibration of Automatic Potentiometric Titrator

Learn how to calibrate the Automatic Potentiometric Titrator using Disodium tartarate as standard.
Turn the instrument & printer on.

Repeatability of Factor Determination

Go to titer mode.
Use Disodium tartrate as standard.
Take all precautions to avoid variations due to weighing & transfer of standard.
Enter sample weight.
Find out the factor.
Take five readings.
Calculate %RSD & average of five.
%RSD of five readings should be less than 0.5.

Calibration of Burette

Clean the ICB (Interchangeable burette).
Fill water in the reservoir.
Fill the burette.
Go to AUX functions & set Eject volume to 0.10ml.
Quit & then press Eject.
Collect the volume in clean, dry, & previously weighed beaker.
Weigh the beaker & find out the weight of ejected volume, further find out the volume.
Volume = Weight in g / 0.99602
Volume should be between 0.0990ml to 0.1010 ml.
Fill the burette.
Go to AUX functions & set Eject volume to 1.0ml.
Quit & then press Eject.
Collect the volume in clean, dry, & previously weighed beaker.
Weigh the beaker & find out the weight of ejected volume, further find out the volume.
Volume = Weight in g / 0.99602
Volume should be between 0.99ml to 1.01 ml.
Fill the burette.
Go to AUX functions & set Eject volume to 10.0ml.
Quit & then press Eject.
Collect the volume in clean, dry, & previously weighed beaker.
Weigh the beaker & find out the weight of ejected volume, further find out the volume.
Volume = Weight in g / 0.99602
Volume should be between 9.98ml to 10.02 ml.
Fill the burette.
Go to AUX functions & set Eject volume to 20.0ml.
Quit & then press Eject.
Collect the volume in a clean, dry, & pre-weighed beaker.
Weigh the beaker & find out the weight of ejected volume, further find out the volume.
Volume = Weight in g / 0.99602
Volume should be between 19.97ml to 20.03 ml.

Precautions

Clean the ICB with acetone after calibration of burette is over.

Frequency

Once in three months.

REFERENCE

User’s guide for Automatic Potentiometric Titrator
Indian Pharmacopoeia
A]  Repeatability of factor determination

Sr. No.

             Burette Reading (in ml.)

Factor
Average
% RSD
1
2
3
4
5
ACCEPTANCE CRITERIA
% RSD Not more than 0.5%.

B]  Calibration of Burette.

    S. No.

Volume (ml.)

I

II

III

IV
Limit (ml.)

Empty Beaker Wt. (g.)

Wt. of Beaker + Water (g.)

II –I

III / 0.99602

1

0.1

 

0.0990 to 0.1010

2

1.0

 

0.99 to 1.01

3

10.0

9.98 to 10.02

4

20.0

19.97 to 20.03
CONCLUSION –
Calibration Complies / Does not comply as per Standard Calibration Procedure.
Next Calibration Due On -
Done By :
Date :
Checked By :
Date :





Ankur Choudhary is India's first professional pharmaceutical blogger, author and founder of Pharmaceutical Guidelines, a widely-read pharmaceutical blog since 2008. Sign-up for the free email updates for your daily dose of pharmaceutical tips.
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