Determination of Ethanol-Soluble Extractive : Pharmaguideline

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Determination of Ethanol-Soluble Extractive

Learn how to determine the Ethanol-Soluble Extractive in Pharmaceutical Ingredients.
Macerate 5 g of the air-dried drug, coarsely powdered, with 100 ml of ethanol of the specified strength in a closed flask for 24 hours, shaking frequently during the first 6 hours and allowing to stand for 18 hours. Thereafter, filter rapidly taking precautions against loss of ethanol, evaporate 25 ml of the filtrate to dryness in a tared flat-bottomed shallow dish, dry at 105° and weigh. Calculate the percentage of ethanol-soluble extractive with reference to the air-dried drug.

Ankur Choudhary is India's first professional pharmaceutical blogger, author and founder of, a widely-read pharmaceutical blog since 2008. Sign-up for the free email updates for your daily dose of pharmaceutical tips.
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