High Performance liquid Chromatography also known as HPLC is a widely used instrument for analysis in pharmaceutical, chemical and food industries. It has powerful ability to identify and quantify the complex mixtures and this makes it an essential instrument for analytical laboratories. This article will provide detailed knowledge on major components, working and principle of HPLC.
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Steps for Analytical Method Development
Analytical methods in chemistry context entail how chemical components in natural materials or synthetic materials are identified, separated and then quantified. Analytical method development is a process whose main purpose is to prove if any analytical method in the pharmaceutical industry is suitable to be used in the measurement of API.
Difference between C8 and C18 Columns Used in HPLC System
High Performance Liquid Chromatography system (HPLC) refers to a technique in analytical chemistry that is used to identify, separate and quantify each component in a mixture. C8 and C18 both refer to the alkyl chain of a bonded face of a column. They are both used in the high performance liquid chromatography system. The two columns have some similarities, but they are also different in some way…
System Suitability in HPLC Analysis
HPLC, short for High-performance liquid chromatography is a technique used for separating the components in a mixture. In the HPLC technique, a liquid sample is passed over an absorbent material to test its efficacy.
HPLC chromatography technique is used in pharmaceutical industries for research and testing purposes. Most of the pharmaceutical companies follow a three-step approach to check the f…
HPLC chromatography technique is used in pharmaceutical industries for research and testing purposes. Most of the pharmaceutical companies follow a three-step approach to check the f…
Difference Between Paddle and Basket Dissolution
When a drug is ingested orally, it takes some time to dissolve in the stomach and get absorbed by the body. The rate at which the drug dissolves inside the stomach affects the drug's concentration in the blood as it gets absorbed. If it dissolves too fast it may cause an over-dosage, and if it dissolves too slowly it may cause an under-dosage.
SOP for Disinfectant Efficacy Test
1.0 OBJECTIVE
To determine the efficacy of disinfectants.
2.0 SCOPE This procedure is applicable for all the disinfectants used for disinfection at manufacturing plant.
3.0 RESPONSIBILITY QC-Microbiologist
4.0 ACCOUNTABILITY Head QC
5.0 ACCOUNTABILITY Head QC
PROCEDURE 5.1 Principle: The disinfectant efficacy is based on the ability to reduce the microbial population by 90% within 15 minutes.…
2.0 SCOPE This procedure is applicable for all the disinfectants used for disinfection at manufacturing plant.
3.0 RESPONSIBILITY QC-Microbiologist
4.0 ACCOUNTABILITY Head QC
5.0 ACCOUNTABILITY Head QC
PROCEDURE 5.1 Principle: The disinfectant efficacy is based on the ability to reduce the microbial population by 90% within 15 minutes.…
SOP for Lal Test by Gel Clot Method
1.0 OBJECTIVE
To define the procedure of LAL test by Gel-Clot Method for better and error-free use of the same.
2.0 SCOPE This procedure is applicable to perform LAL test by Gel-Clot method.
3.0 RESPONSIBILITY 3.1 Doing: Technical Assistant / Executive
3.2 Checking: Executive /Manager
4.0 ACCOUNTABILITY Head of the department.
5.0 PROCEDURE 5.1 Material required
a. Limulus Amebocyte Lysate (0…
2.0 SCOPE This procedure is applicable to perform LAL test by Gel-Clot method.
3.0 RESPONSIBILITY 3.1 Doing: Technical Assistant / Executive
3.2 Checking: Executive /Manager
4.0 ACCOUNTABILITY Head of the department.
5.0 PROCEDURE 5.1 Material required
a. Limulus Amebocyte Lysate (0…
