Preparation and Standardization of 0.1 M Sodium Hydroxide : Pharmaceutical Guidelines

Preparation and Standardization of 0.1 M Sodium Hydroxide

Preparation and standardisation of 0.1 M Sodium Hydroxide using Benzoic acid and Thymolphthalein solution as indicator.

Sodium Hydroxide Solution Preparation:

•  Take about 100ml of distilled water in a cleaned and dried 1000 ml volumetric flask.
•  Add about 4.2 gm of Sodium hydroxide with continues stirring.
•  Add more about 700ml of distilled water, mix and allow to cool to room temperature.
•  Make up the volume 1000 ml with distilled water. Mix solution thoroughly.
•  Keep the solution for at least an hour and then carry out the standardization.

Sodium Hydroxide Solution Standardization:

•  Accurately weigh about 0.5 g of potassium biphthalate, previously crushed lightly and dried at 120° for 2 hours.
•  Dissolve in 75 ml of carbon dioxide free water.
•  Add 2 drops of phenolphthalein, and titrate with the sodium hydroxide solution to the production of a permanent pink color.
•  Each 20.42 mg of potassium biphthalate is equivalent to 1 ml of 0.1N sodium hydroxide.


        Wt. in gm of potassium bisulphate
M= ------------------------------------------
          0.20423 x ml NaOH solution

Also see: Determination of Shelf Life of Solutions in Laboratory

Ankur Choudhary is India's first professional pharmaceutical blogger, author and founder of Pharmaceutical Guidelines, a widely-read pharmaceutical blog since 2008. Sign-up for the free email updates for your daily dose of pharmaceutical tips.
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