Preparation and standardisation of 0.1 M Ferric Ammonium Sulphate solution using Sodium Thiosulphate and starch solution as indicator used in chemical analysis of pharmaceutical substances.
Ferric Ammonium Sulphate Solution Preparation
- Dissolve 50 g of ferric ammonium sulfate in a mixture of 300 ml of water and 6 ml of sulphuric acid.
- Dilute with sufficient freshly boiled and cooled water to produce 1000 ml.
- Standardise the solution in the following manner.
Ferric Ammonium Sulphate Solution Standardization
- To 25.0 ml add 3 ml of hydrochloric acid and 2 g of potassium iodide.
- Allow standing for 10 minutes.
- Titrate the liberated iodine with 0.1 M sodium thiosulphate using starch solution, added towards the end of the titration, as an indicator.
- 1 ml of 0.1 M sodium thiosulphate is equivalent to 0.04822 g of FeNH4(SO4)2.12H2O.
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Dr. Ankur Choudhary is a prominent Pharmaceutical Quality Assurance expert, consultant and the founder of Pharmaguideline. With over 22 years of hands-on experience in cGMP-compliant manufacturing environments, he specializes in establishing validation protocols, sterile area controls and data integrity systems. Ankur routinely interprets international regulatory frameworks (including FDA, EMA and ICH guidelines) to help global pharmaceutical professionals ensure strict regulatory compliance and operational excellence. Connect with Ankur on LinkedIn. Need Help: Ask Question
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