Preparation and standardisation of 0.1 M Ferrous Ammonium Sulphate using Ceric Ammonium Sulphate and Orthophenanthroline solution as indicator that is used in pharmaceutical analysis.
Ferrous Ammonium Sulphate Solution Preparation
- Dissolve 40 g of ferrous ammonium sulfate in a previously cooled mixture of 40 ml of sulphuric acid and 200 ml of water.
- Dilute with sufficient freshly boiled and cooled water to produce 1000 ml.
- Standardize the solution in the following manner.
Ferrous Ammonium Sulphate Solution Standardization
- Measure accurately 25.0 ml of the solution into a flask.
- Add 2 drops of Orthophenanthroline solution.
- Titrate with 0.1 M ceric ammonium sulfate until the red color is changed to pale blue.
- 1 ml of 0.1 M ceric ammonium sulfate is equivalent to 0.03921g of Fe(NH4)2(SO4)2.6H2O.
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Dr. Ankur Choudhary is a prominent Pharmaceutical Quality Assurance expert, consultant and the founder of Pharmaguideline. With over 22 years of hands-on experience in cGMP-compliant manufacturing environments, he specializes in establishing validation protocols, sterile area controls and data integrity systems. Ankur routinely interprets international regulatory frameworks (including FDA, EMA and ICH guidelines) to help global pharmaceutical professionals ensure strict regulatory compliance and operational excellence. Connect with Ankur on LinkedIn. Need Help: Ask Question
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