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Preparation and Standardization of 0.0005 M Dioctyl Sodium Sulphosuccinate

Preparation and standardisation of 0.0005 M Dioctyl Sodium Sulphosuccinate using anhydrous Sodium Sulphate, Sodium Carbonate, Chloroform and Bromophenol Blue solution as indicator used in pharmaceutical analysis.

Dioctyl Sodium Sulphosuccinate Solution Preparation

•  Dissolve 0.225 g of dicotyl sodium sulphosuccinate in warm water.
•  Cool and dilute to 1000 ml with water.
•  Standardize the solution in the following manner.

Dioctyl Sodium Sulphosuccinate Solution Standardization

•  To 25.0 ml add 25.0 ml of a solution containing 20 % w/v of anhydrous sodium sulphate and 2 % w/v sodium carbonate, 50 ml of chloroform and 1.5 ml of bromophenol blue solution and mix.
•  Titrate with 0.01 M tetrabutylammonium iodide until about 1 ml remains to be added for the end-point.
•  Stopper the flask, shake vigorously for 2 minutes and continue the titration, in increments of 0.5 ml, shaking vigorusly and allowing the flask to stand for about 10 seconds after each addition. 
•  Continue the titration until a blue colour just appears in the chloroform layer.
•  1 ml of 0.01 M tetrabutylammonium iodide is equivalent to 0.004446 g of C20H37NaO7S.

Also see: Determination of Shelf Life of Solutions in Laboratory

Ankur Choudhary is India's first professional pharmaceutical blogger, author and founder of Pharmaceutical Guidelines, a widely-read pharmaceutical blog since 2008. Sign-up for the free email updates for your daily dose of pharmaceutical tips.
Email: .moc.enilediugamrahp@ofni Need Help: Ask Question

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