Preparation and Standardization of 0.02 M Cupric Sulphate : Pharmaguideline

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Preparation and Standardization of 0.02 M Cupric Sulphate

Preparation and standardisation of 0.02 M Cupric Sulphate solution using Disodium Edetate and Pyridylazonaphthol solution as indicator that is used in pharmaceutical analysis.

Cupric Sulphate Solution Preparation

  • Dissolve 5.0 g of cupric sulfate in water and dilute to 1000 ml with water.
  • Standardize the solution in the following manner.

Cupric Sulphate Solution Standardization

  • To 20.0 ml add 2 g of sodium acetate.
  • Titrate with 0.02 M disodium edetate, using 0.1 ml of pyridylazonaphthol solution as an indicator, until the color changes from violet-blue to bright green, adding the titrant slowly towards the end-point.
  • 1 ml of 0.02 M disodium edetate is equivalent to 0.004994 g of CuSO4.5H2O.
Also see: Determination of Shelf Life of Solutions in Laboratory

Ankur Choudhary is India's first professional pharmaceutical blogger, author and founder of, a widely-read pharmaceutical blog since 2008. Sign-up for the free email updates for your daily dose of pharmaceutical tips.
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