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Calibration of Melting Point Apparatus


Learn how to calibrate the Melting Point Apparatus using Vanillin, Acetanilide, Urea, Sulphanilamide, Caffeine and Diclofenac Sodium.

Procedure

1.  Ensure that all the connections of the instrument are proper.
2.  Operate the instrument as per the operating instructions and determine the melting point of the following reference substances. 
3.  Take the reference substances from lowest range to highest range at a time for calibration.

Reference Substances
Standard Range
Vanillin
81.0°C – 83.0°C
Acetanilide
114.0°C – 116.0°C
Urea (finely crushed)
132.0°C – 135.0°C
Sulphanilamide
164.5°C – 166.5°C
Caffeine (dried at 100°C)
234.0°C – 237.0°C
Diclofenac Sodium
277.0°C – 283.0°C

Acceptance criteria

The melting point of the reference substances should be within the standard range.

Frequency 

Once in a month

Maintenance / Repairs

When the instrument does not comply with the requirement / tolerance range specified above, the instrument should be labeled “OUT OF CALIBRATION” and should be repaired / serviced.
After repair / maintenance, calibrate the instrument.
Ankur Choudhary is India's first professional pharmaceutical blogger, author and founder of Pharmaceutical Guidelines, a widely-read pharmaceutical blog since 2008. Sign-up for the free email updates for your daily dose of pharmaceutical tips.
Email: .moc.enilediugamrahp@ofni Need Help: Ask Question


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