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Mean Kinetic Temperature (MKT) in Stability Studies

Learn how to calculate the Mean Kinetic Temperature (MKT) in stability studies of pharmaceutical drugs.
Mean Kinetic Temperature is a useful tool used in pharmaceutical stability studies. It helps to calculate the degradation of stability sample.

Mean Kinetic Temperature can be defined as a single calculated temperature which degrades the same amount of the drug as degraded by the different temperatures during the particular time period. MKT is not a simple arithmetic mean but is is calculated from the temperatures of a stability chambers. Some software are available that stores the temperature from the stability chambers and also calculate the mean kinetic
temperature directly.

Related: Guidelines for Pharmaceutical Stability Study

Degradation of any drug totally depends upon its storage temperature. When tablets are stored in a stability temperature, its temperature does not remain constant always. It varies up and down from the set temperature.

Suppose we set a stability chamber at 30°C but it shall be 29.4, 29.8 or 30.6 many times in the specified period of time and we found the degradation of drug by 0.6% in that period. Now mean kinetic temperature is calculated to determine the single temperature at which the drug would degrade by 0.6% in that period.

Ankur Choudhary is India's first professional pharmaceutical blogger, author and founder of Pharmaceutical Guidelines, a widely-read pharmaceutical blog since 2008. Sign-up for the free email updates for your daily dose of pharmaceutical tips.
Email: .moc.enilediugamrahp@ofni Need Help: Ask Question

1 Comment so far : Add yours...

jitendra B. Singh said...

Pl inform
is MKT required for API stability studies? If yes, pl also provide appropriate reason..

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