Poly Alpha Olefin (PAO) is used for HVAC qualification in pharmaceuticals. PAO is used as a replacement of the DOP (Dioctyl Phthalate) that was used for this purpose from a long time.
Dioctyl Phthalate is found as a carcinogen (cause cancer) for human. Scientists were trying to find a material to replace the DOP from a long time. Finally in 2001 Japan Air Cleaning Association (JACA) published a guideline to replace the DOP with PAO. It gives the equal performance to the DOP and doesn’t have any harmful effect on health. FDA also clearly says that alternative aerosols are also acceptable but they should not promote the microbial growth in area. Therefore, it is recommended to replace the Dioctyl Phthalate with Poly Alpha Olefin (CAS #68649-12-7). The size of PAO generated aerosol ranges from 0.1 to 1.0 μm. The PAO aerosols are generated by aerosol generator and passed through the HEPA filter then the integrity is checked using a photometer. 99.97% particles having size larger than 0.3 μm should not be passed through HEPA filters.
|Molecular Structure of Alpha Olefin|
Shelf life of the poly alpha olefin is 10 years in sealed container but for opened container it is one year. It should be protected from UV light and direct sunlight.
Ankur Choudhary is India's first professional pharmaceutical blogger, author and founder of Pharmaceutical Guidelines, a widely-read pharmaceutical blog since 2008. Sign-up for the free email updates for your daily dose of pharmaceutical tips.
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