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Poly Alpha Olefin (PAO) Used in HVAC Validation


Know more about the Polyalphaolefin (PAO) used in HEPA filter integrity test during HVAC system qualification including their molecular structure.
Poly Alpha Olefin (PAO) is used for HVAC qualification in pharmaceuticals. PAO is used as a replacement of the DOP (Dioctyl Phthalate) that was used for this purpose from a long time.

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Alpha Olefin Aerosol GeneratorDioctyl Phthalate is found as a carcinogen (cause cancer) for human. Scientists were trying to find a material to replace the DOP from a long time. Finally in 2001 Japan Air Cleaning Association (JACA) published a guideline to replace the DOP with PAO. It gives the equal performance to the DOP and doesn’t have any harmful effect on health. FDA also clearly says that alternative aerosols are also acceptable but they should not promote the microbial growth in area. Therefore, it is recommended to replace the Dioctyl Phthalate with Poly Alpha Olefin (CAS #68649-12-7). The size of PAO generated aerosol ranges from 0.1 to 1.0 μm. The PAO aerosols are generated by aerosol generator and passed through the HEPA filter then the integrity is checked using a photometer. 99.97% particles having size larger than 0.3 μm should not be passed through HEPA filters.

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Molecular Structure of Alpha Olefin
Poly alpha olefin is a polymer of alpha olefin. Alpha olefin is a class of olefins those have double bond between first and second carbons of the polymer chains. PAO is a mixture of the dimers, trimers and tetramers of the 1-octene, 1-decene and 1-dodecene. Poly alpha olefins have good lubrication properties and greater viscosity than mineral oils. Poly alpha olefins are also used as synthetic lubricants and as a coolant in radiators.

Shelf life of the poly alpha olefin is 10 years in sealed container but for opened container it is one year. It should be protected from UV light and direct sunlight.
Ankur Choudhary is India's first professional pharmaceutical blogger, author and founder of Pharmaceutical Guidelines, a widely-read pharmaceutical blog since 2008. Sign-up for the free email updates for your daily dose of pharmaceutical tips.
Email: .moc.enilediugamrahp@ofni Need Help: Ask Question


2 Comments so far : Add yours...

vikram sudesh said...

Is PAO can be used in ULPA filter integrity test where pore size is 0.12 micron in compare to HEPA 0.3micron

Dadasaheb Deshmukh said...

Yes.

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