Rapid mixer granulator is widely used equipment in pharmaceutical manufacturing. It is used to mix the pharmaceutical ingredients and make the granules before compression. Impellers and chopper are mainly responsible for wet granulation in the rapid mixer granulator.
Impellers: Impellers are fixed at the bottom of the dome shaped stainless steel bowl. It has two full length and two half length blades. These impellers are designed in such a way that small blades lift the material and full length blades push the material to mix well. These impellers break up the wet mass into small pieces and granules.
Chopper: These are specially designed small blades located at the bottom of the dome. It rotates at high speed (1440/2880) RPM to give easy and uniform granulation. Chopper cuts the wet lumps of material into small sized parts those are mixed equally by the impellers and its speed is responsible for the size of the granules. Chopper doesn't have any significant effect on the granule size when impeller speed is high (above 200 RPM).
Discharge Port: A discharge port is located horizontally at bottom of the dome. Granules are unloaded in the container through the discharge port. Opening of discharge port is operated by a compressed air regulated cylinder known as pneumatic cylinder that requires 3-5 kg/cm2 pressure of compresses air.
Related: Dry Granulation Process
Principle of Working:
In rapid mixer granulator, formation of granules occurs by rising, whirling and tumbling motion of material. Dry mixing is done by adding all ingredients into the RMG by rotation of impeller and chopper at high speed. During the addition of binder solutions to the powder impeller and chopper are operated at low speed. After the formation of wet mass impeller and chopper are operated at high speed to form the granules of required size.
Dry mixing takes about 3-5 minutes to mix the ingredients, wet mixing takes 5-10 minutes to make the wet mass of material while the granulation process takes 5-10 minutes to make 0.5 mm to 1.5 mm sized granules. Mixing time consumed in processing is depends upon the ingredients quantity and their particle size.
Ankur Choudhary is India's first professional pharmaceutical blogger, author and founder of Pharmaceutical Guidelines, a widely-read pharmaceutical blog since 2008. Sign-up for the free email updates for your daily dose of pharmaceutical tips.
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