Preparation and Standardization of 0.5 M Methanolic Hydrochloric Acid : Pharmaceutical Guidelines

Preparation and Standardization of 0.5 M Methanolic Hydrochloric Acid

Preparation and standardisation of 0.5 M Methanolic Hydrochloric Acid using anhydrous Sodium Carbonate and Methyl Red solution as indicator used in analysis of pharmaceutical ingredients.

Methanolic Hydrochloric Acid Solution Preparation

•  Take 40 ml of water in a 1000 ml volumetric flask.
•  Slowly add 43 ml of hydrochloric acid.
•  Cool and add methanol to volume.
•  Standardize the solution in the following manner.

Methanolic Hydrochloric Acid Solution Standardization

•  Weigh accurately about 800 mg of anhydrous sodium carbonate, previously heated at about 270° for 1 hour.
•  Dissolve it in 100 ml of water and add 0.1 ml of methyl red solution.
•  Add the acid slowly from a burette, with constant stirring, until the solution becomes faintly pink.
•  Heat the solution to boiling, cool and continue the titration.
•  Heat again to boiling and titrate further as necessary until the faint pink color is no longer affected by continued boiling.
•  1 ml of 0.5 M hydrochloric acid is equivalent to 0.02650 g of Na2CO3.
•  Calculate molarity of solution by following formula:

            Na2CO3 in mg
M = --------------------------
         HCl in ml  x 26.50

Also see: Determination of Shelf Life of Solutions in Laboratory

Ankur Choudhary is India's first professional pharmaceutical blogger, author and founder of Pharmaceutical Guidelines, a widely-read pharmaceutical blog since 2008. Sign-up for the free email updates for your daily dose of pharmaceutical tips.
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