Preparation and Standardization of 1 M Nitric Acid : Pharmaceutical Guidelines

Preparation and Standardization of 1 M Nitric Acid

Preparation and standardisation of 1 M Nitric Acid using anhydrous Sodium Carbonate and Methyl Orange solution as indicator used in pharmaceutical analysis.

Nitric Acid Solution Preparation

•  Dilute 63 ml of nitric acid with sufficient water to produce 1000 ml.
•  Standardize the solution in the following manner.

Nitric Acid Solution Standardization

•  Dissolve 2 g of anhydrous sodium carbonate in 50 ml of water.
•  Titrate with the nitric acid solution using methyl orange solution as indicator until the solution becomes reddish yellow. 
•  Boil for 2 minutes, cool and continue the titration until the reddish yellow color is restored.
•  1 ml of 1 M nitric acid is equivalent to 0.053 g of Na2CO3.
•  Calculate molarity of solution by following formula:

           Na2CO3 in mg
M = --------------------------
         HNO3 in ml  x 53

Also see: Determination of Shelf Life of Solutions in Laboratory

Ankur Choudhary is India's first professional pharmaceutical blogger, author and founder of Pharmaceutical Guidelines, a widely-read pharmaceutical blog since 2008. Sign-up for the free email updates for your daily dose of pharmaceutical tips.
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