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SOP for Cleaning of Karl Fischer Apparatus

Standard operating procedure to clean the karl fischer apparatus.
2024-04-17T12:25:44Z PrintOnline CoursesQuestion Forum No comments
✔ Technical Review by: | Last Verified:2024-04-17T12:25:44Z

1.0 OBJECTIVE

To clearly lay down the procedure for cleaning.

2.0 SCOPE

This procedure is applicable to Karl Fischer apparatus, installed in quality control laboratory.

3.0 RESPONSIBILITY

3.1 Doing: Technical Assistant
3.2 Checking: Executive/Manager

4.0 ACCOUNTABILITY

Head of the Department

5.0 PROCEDURE

5.1 After completion of the testing, press FLUSH switch for flushing of Karl Fischer reagent into a storage bottle.
5.2 Remove the solution from the test compartment and wash with methanol which is used for water determination. Wipe the knob of sample compartment with tissue paper.
5.3 Switch ‘OFF’ the instrument and switch ‘OFF’ the mains.
5.4 Collect the waste solution into the waste beaker at the same time all waste to be thrown to avoid corrosion.
5.5 Clean the outer surface of the instrument with isopropyl alcohol and dry it with tissue paper.
5.6 Keep the record in the log card of instrument

6.0 ABBREVIATION

6.1 SOP - Standard Operating Procedure
Get ready to use editable SOPs in MS-Word FormatView List




is a prominent Pharmaceutical Quality Assurance expert, consultant and the founder of Pharmaguideline. With over 22 years of hands-on experience in cGMP-compliant manufacturing environments, he specializes in establishing validation protocols, sterile area controls and data integrity systems. Ankur routinely interprets international regulatory frameworks (including FDA, EMA and ICH guidelines) to help global pharmaceutical professionals ensure strict regulatory compliance and operational excellence. Connect with Ankur on LinkedIn. Need Help: Ask Question

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