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SOP for Cleaning of Gas Chromatograph (Head Space)

Standard operating procedure to clean the head space gas chromatograph.
2024-04-17T12:28:36Z PrintOnline CoursesQuestion Forum No comments
✔ Technical Review by: | Last Verified:2024-04-17T12:28:36Z

1.0 OBJECTIVE

To lay down the procedure for cleaning of headspace gas chromatograph.

2.0 SCOPE

This procedure is applicable to clean the gas chromatograph, installed in the quality control department.

3.0 RESPONSIBILITY

3.1 Doing: Technical Assistant, Executive
3.2 Checking: Executive/Manager

4.0 ACCOUNTABILITY

Head of the Department

5.0 PROCEDURE

5.1 Switch ‘OFF ’ the instrument.
5.2 Switch ‘OFF’ the Mains.
5.3 Clean the outer surface of the instrument with a dry clean cotton cloth.
5.4 Wash the syringe with distilled water for several times.
5.5 Flush the column with the carrier gas for stabilization column.
5.6 Clean the headspace autosampler vial with D.M.water for several times and dry the vial in the oven for further use.

6.0 ABBREVIATIONS

6.1 SOP - Standard Operating Procedure
6.2 D.M.water = Demineralise water
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is a prominent Pharmaceutical Quality Assurance expert, consultant and the founder of Pharmaguideline. With over 22 years of hands-on experience in cGMP-compliant manufacturing environments, he specializes in establishing validation protocols, sterile area controls and data integrity systems. Ankur routinely interprets international regulatory frameworks (including FDA, EMA and ICH guidelines) to help global pharmaceutical professionals ensure strict regulatory compliance and operational excellence. Connect with Ankur on LinkedIn. Need Help: Ask Question

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