Determination of Freezing Point : Pharmaceutical Guidelines

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Determination of Freezing Point

Learn how to determine the Freezing Point of pharmaceutical substances using saturated solution of sodium chloride.
The freezing point is the maximum temperature occurring during the solidification of a super-cooled liquid.

Apparatus

The apparatus and its dimensions are as shown in the figure.

Method

Freezing PointPlace a quantity of the substance under examination in the inner tube such that the thermometer bulb is well covered and determine the approximate freezing point by cooling rapidly.

Place the inner tube in a bath about 5° above the approximate freezing point until all but the last traces of crystals are melted. Fill the beaker with water or a saturated solution of sodium chloride at a temperature about 5° lower than the approximate freezing point, assemble the apparatus, ensuring that some seed crystals are present, and stir thoroughly until solidification takes place. The highest temperature observed during solidification of the substance is regarded as the freezing point of the substance.






Ankur Choudhary is India's first professional pharmaceutical blogger, author and founder of Pharmaceutical Guidelines, a widely-read pharmaceutical blog since 2008. Sign-up for the free email updates for your daily dose of pharmaceutical tips.
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