SOP for Calibration of pH Meter Temperature Sensor : Pharmaceutical Guidelines

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SOP for Calibration of pH Meter Temperature Sensor

Standard operating procedure for the calibration of pH meter temperature sensor using water for injection (WFI) / purified water (PW).

1.0 Objective

To provide a standard operating procedure for the calibration of pH meter temperature sensor.

2.0 Scope

This procedure is applicable to pH meter.

3.0 Responsibility

3.1 Doing: Technical Assistant/Executive
3.2 Checking: Executive /Manager

4.0 Accountability

Head of the Department

5.0 Procedure

Frequency: Twice in Year.
5.1 Calibration Procedure for pH meter temperature sensor
5.1.1 Keep the sensor probe of reference calibrated digital thermometer in the beaker containing water for injection (WFI) / purified water (PW) of about temperature 35°C.
5.1.2 Add cold WFI/PW slowly drop wise and bring the temp. between 27°C to 30°C.
5.1.3 Compare the temp. shown by reference calibrated digital thermometer and pH meter & record it in format as Annx. I.
5.1.4 Add WFI/PW in some more quantity slowly drop wise to bring the temp. between 26°C to 23°C.
5.1.5 Compare the temp. shown by reference calibrated digital thermometer and pH meter & record it in format as Annx. I.
5.1.6 Add cold WFI/PW slowly drop wise and bring the temp. between 20°C to 22°C.
5.1.7 Compare the temp. shown by reference calibrated digital thermometer and pH meter & record it in format as Annx. I.
5.1.8 Acceptance Criteria : ± 3°C

6.0 Abbreviations

6.1 °C= Degree centigrade

ANNEXURE-I
Q. C. Department
PH METER TEMPERATURE SENSOR RECORDS
                                                                   
REF.No. :_________________
ISSUE DATE: _________________
ISSUED BY :____________________   



Calibrated  Ref. Digital Thermometer No.:____________________ 
Ref. Thermometer Calibration date          :____________________
Ref. Thermometer Certificate No.            :____________________
Ref. Thermometer Calibration Due Date  : ____________________
pH meter ID.No.                                      : ___________________
Results Observed:
Set Range
Observation
Difference
tolerance
Temperature as read on pH meter
Temperature as on read on display of Ref. Thermo.
30°C to 27°C



±0.3°C
26°C to 23°C



22°C to 20°C




Remarks                 :
Calibration date          :
Next Calibration date  :
Calibrated  by             :
Checked by                 :
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Ankur Choudhary is India's first professional pharmaceutical blogger, author and founder of Pharmaceutical Guidelines, a widely-read pharmaceutical blog since 2008. Sign-up for the free email updates for your daily dose of pharmaceutical tips.
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