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Methods to Determine End Point of Potentiometric Titration and Applications

Titrations by potentiometry, Methods to determine the endpoint- Acid-base titration, Precipitation titration, Complexometric titration etc.
By measuring the addition of titrant until the entire test substance undergoes reactions, the amount of a given test substance can be determined. Through this process after the titration, the potential difference between the electrodes (namely the reference electrode and the indicator electrode) is determined under conditions in which the equilibrium of thermodynamics is maintained and no disturbance of thermodynamic equilibrium results from the current passing through the electrodes.

Potentiometric titration is a method used in laboratories for measuring analytes' concentration. Analytes are characterized using this method. There are no chemical indicators involved with this method. The electrostatic potential is instead measured across the material.

The volumetric method involves measuring the potential between two electrodes (reference and indicator) concerning the volume of reagent added.

Titrations by potentiometry

Potentiometric titration and acid-base titration are two of their categories. Redox titration, complexometric titration, and precipitation titration are the remaining two. The types of titration are briefly described below.

Acid-base titrations - Potentiometric acid-base titrations are used to measure the concentration of an acid/base by neutralizing it exactly with a standard solution or acid/base that is known to have a known concentration.

Redox titrations - Redox reactions are performed between analyte and titrant in this potentiometric titration. Titration of an iodine solution using a reducing agent to produce iodide ions (the endpoint of the test is determined by a starch indicator).

Complexometric titrations - Alternatively, it can also be called keratometry. During the titration process, a colored complex forms to indicate the end of the titration process. A solution can be determined to have the composition of metallic ions using this method.

Precipitation titrations - An insoluble precipitate is formed through the reaction between analyte and titrant in precipitation titrations. During this titration, the end-point is reached when there is no longer a precipitate formed after the addition of titrant.

Methods to determine the endpoint

Acid-base titration

Acids and bases with high solubility are used as standard solutions for neutralization titrations. The titration can be performed either with an acidic or a basic solution, but it is recommended that both acidic and basic standard solutions are available just in case a back-titration is needed to confirm the endpoint. By titrating a solution against a primary standard, one can determine its concentration. By measuring 1.000 mL of the base and the acid concentration in this ratio, we can determine the concentration of the other.

Precipitation titration

Titrations based on precipitates that form slightly soluble precipitates are called "precipitation titrations". The precipitating titration utilizing silver nitrate establishes the polarity of the precipitates. If it precipitates with (AgNO3) then the process is called argentometric. Titration by precipitation is extremely useful since it allows us to determine the concentration of halogens and some metal ions. An example of a Titration of Cl- & Br- & I- with AgNO3 could be found in Example 1.

Complexometric titration

Electron acceptors (electron donors) react with complexions (coordination compounds) to form complex ions. At least one unshared electron pair must be present in the donor species (or ligand) to form a bond. An electrode mixture containing Bi3+, Cd2+, and Ca2+ for determining many cations using EDTA and metal electrodes!

Oxidation-reduction reaction

Titrations performed with redox analytes are based on redox reactions between analytes and titrants. The use of a potentiometer and a redox indicator is commonly used for measuring redox potential. The most common redox titration methods use a reducing agent and starch to determine the redox state of iodine solutions. After being introduced to starch, iodine forms a blue-red complex. It is possible to reduce iodine (I2) to iodide (I-) using substances such as thiosulfate (S2O3 2-), and at the end of this process, the blue color will disappear. An iodometric titration is carried out in this manner.

General methods for potentiometry

Electrodes attached to positive and negative terminals are used in a dismantling structure. In addition to zeroing the meter, standardizing the electrode system is also necessary because subsequent readings must be taken while the stirrer motor is running. Put the beaker and electrodes into a separate container and thoroughly rinse them. Next, pour the titrated solution into the container and measure how much is in it. Then, with a stirring device running, check the pH of the solution. Measure the pH of the solution after mixing the 2ml of titrant, but provide adequate time for the solution to be mixed. To reach the endpoint, add additional quantities of titrant and when the endpoint is reached, reduce to 0.1ml increments and measure the resulting pH values. After the equivalence point has passed, you should continue to measure pH for about 5ml more. Turn off the stirring device and the pH meter will be on standby. Fill the beaker with distilled water and thoroughly wash the electrodes in it. Plot pH as a function of the titrant added. The equivalence point is used as the reference point for calculating any required data.


Clinical chemistry - As an analyte in complex matrices is selective for ion-selective electrodes in clinical chemistry, they are valuable sensors. Typically, analytes such as sodium, potassium, calcium, hydrogen, and chlorine, and dissolved gases such as CO2 are used

Environmental chemistry - CN-, NO3, F3, and NH3 in water and wastewater are measured using environmental chemistry.

Potentiometric titrations - An acid-base titration is potentiometrically conducted to determine the equivalence point. Chemical reactions such as redox processes, precipitation, acids, bases, complexations, and other chemical reactions may be titrated in aqueous and non-aqueous solvents.

Agriculture - The following elements are found in soils, plant materials, feed stuff, and fertilizers: NO3, NH4, I, Ca, K, and CN.Detergent manufacturing - Studying the effects of detergent manufacturing using calcium, barium, and fluorine.
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Ankur Choudhary is India's first professional pharmaceutical blogger, author and founder of, a widely-read pharmaceutical blog since 2008. Sign-up for the free email updates for your daily dose of pharmaceutical tips.
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  1. Thank you so much this is very useful and helpful


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