Partially Miscible Liquids, Critical Solution Temperature and Applications : Pharmaguideline

Online GMP Courses with Certificate


Partially Miscible Liquids, Critical Solution Temperature and Applications

The dissolved state of each liquid is found to be in two layers when certain amounts of water and ether are mixed.

Partially miscible liquids

The dissolved state of each liquid is found to be in two layers when certain amounts of water and ether are mixed. Reminding ourselves that partial miscible are partially soluble at different temperatures will suffice here. A conjugate phase, such as phenyl and water, will become identical at the critical solution temperature (or upper convolutional temperature) when the mutual solubilities for each increase with temperature. The temperature at which normal phase separation is formed is called the homogeneous temperature.

For some liquid pairs, the solubility increases as the temperature is lowered, so that the system will demonstrate a lower consolute temperature at which the two members will be soluble in all proportions and at which two liquid layers will form. There is also another type of trajectory, which involves a few mixtures such as nicotine and water, showing a lower and an upper equilibrium temperature along with an intermediate temperature range in which the liquids are only partially miscible. There is no critical solution temperature when it comes to a final type. For example, ethyl ether and water are insoluble at both an upper and a lower solution temperature. When the mixture exists at all temperatures, only a small portion of the mixture is soluble.

Critical solution temperature

If temperatures are raised or lowered, the temperature where complete miscibility is reached - useful for partially miscible liquids that are not miscible in ordinary circumstances.

A mixture will become miscible at a certain temperature if all of its components become soluble. The temperature of the upper critical solution is called the upper solution temperature or upper critical solution temperature. Partially miscible liquids become more soluble at a certain temperature before becoming completely miscible. Temperatures lower than this are known as critical solution temperatures (CST) or solution temperatures. If there is an impurity added, the temperature above the phase may change.

Lower critical solution temperature - Lower than the temperature at which two liquid phases completely mix and behave like a single phase.

Applications of critical solution temperature

Critical solution temperature applications: Impurities in the solution (dissolved in either phase) alter critical solution temperatures and the liquid phase composition at critical solution temperatures. One liquid containing soluble substance will lift the upper CST, whereas one liquid containing insoluble substance will lower the lower CST. One percent of sodium chloride, for instance, would raise CST by 12° in phenol-water systems. It raises the upper CST of phenol-water by about 30° when naphthalene (insoluble in water) is added in about 0.12 molar solution. Liquids that are soluble in both liquids are more likely to lower both CSTs while raising the lower CST. In water and phenol, sodium oleate dissolves separately, for instance. CST value is decreased by 45° upon addition of 1% sodium oleate solution to the phenol-water system.

1. Critical solution temperature can be used to determine the purity of a substance. If there are small amounts of impurities present in CST values, the value will be impacted very strongly. It is usually a linear relationship between CST value and impurity concentration. The CST values of alcohol-cyclohexane systems enable us to estimate the amount of water present in the alcohol.

2. For example, phenolic disinfectants used in water are formulated using this principle. A very small amount of sodium oleate reduced the CST value of the phenol-water system considerably, as illustrated by Cresol with the soap solution. Hence, Lysol-like disinfectants can be made using phenol as an additive to make it completely miscible in water (by adding sodium oleate in the proper amounts).

3. Characterization of polymer mixtures is done by determining the lower critical solution temperature.

4. With the addition of the third substance, the liquids can be separated using this method. A third substance is added to the extraction to extract drugs for analysis.

5. By estimating the percentage of added substances through CST values, the corresponding value can be calculated.
Get subject wise printable pdf documentsView Here

Ankur Choudhary is India's first professional pharmaceutical blogger, author and founder of, a widely-read pharmaceutical blog since 2008. Sign-up for the free email updates for your daily dose of pharmaceutical tips.
.moc.enilediugamrahp@ofni :liamENeed Help: Ask Question

No comments:

Post a Comment

Please don't spam. Comments having links would not be published.

Popular Categories

QA SOPs QC SOPs Micro SOPs HVAC Production SOPs Stores SOPs Checklists Maintenance SOPs HPLC Sterile GLP Validation Protocols Water System GDP Regulatory Maintenance Calibration Warning Letters Education B.Pharmacy
Online Courses

Follow Pharmaguideline



Editable Pharmaceutical Documents in MS-Word Format. Ready to use SOPs, Protocols, Master Plans, Manuals and more...



Recent Posts