Synthesis and Medicinal Uses of Azepines : Pharmaguideline

Online GMP Courses with Certificate

ENROLL

Synthesis and Medicinal Uses of Azepines

When 2-alkoxy-3H-azepines are rearranged intramolecularly with primary/secondary alcohol, the aryl nitrene undergoes ring expansion.
2024-04-17T07:25:18Z PrintOnline CoursesQuestion Forum No comments

Azepines

Synthesis

Tributylphosphine is used to deoxygenate nitrobenzene. When 2-alkoxy-3H-azepines are rearranged intramolecularly with primary/secondary alcohol, the aryl nitrene undergoes ring expansion.




Imipramine synthesis



Carbamazepine synthesis



Medicinal Uses

In the azepine class of drugs, imipramine is often used as an anti-depressant, diazepam as a tranquilizer, temocapril as an ACE-inhibitor and as an antihypertensive, and omapatrilat as an anti-hypertensive drug.
Get subject wise printable pdf documentsView Here




Ankur Choudhary is India's first professional pharmaceutical blogger, author and founder of pharmaguideline.com, a widely-read pharmaceutical blog since 2008. Sign-up for the free email updates for your daily dose of pharmaceutical tips.
.moc.enilediugamrahp@ofni :liamENeed Help: Ask Question

No comments:

Post a Comment

Please don't spam. Comments having links would not be published.


Popular Categories

QA SOPs QC SOPs Micro SOPs HVAC Production SOPs Stores SOPs Checklists Maintenance SOPs HPLC Sterile GLP Validation Protocols Water System GDP Regulatory Maintenance Calibration Warning Letters Education B.Pharmacy
Online Courses


Follow Pharmaguideline


DOCUMENTS

PHARMACEUTICAL DOCUMENTS

Editable Pharmaceutical Documents in MS-Word Format. Ready to use SOPs, Protocols, Master Plans, Manuals and more...

View


adsbypg


Recent Posts