Home › Education › T-BP401 ›

Synthesis and Medicinal Uses of Purine

Traube synthesis - 4-Amino-6-hydroxypyrimidine or 4-diaminopyrimidine is first nitrosated at the 5-position, followed by nitrosation of nitro groups.
2024-04-17T07:19:18Z PrintOnline CoursesQuestion Forum No comments
✔ Technical Review by: | Last Verified:2024-04-17T07:19:18Z

Purine

Synthesis




Traube synthesis - 4-Amino-6-hydroxypyrimidine or 4-diaminopyrimidine is first nitrosated at the 5-position, followed by nitrosation of nitro groups to amino groups using ammonium sulfide, followed by ring closure using formic acid or chlorocarbonic ester.


Caffeine synthesis -


Medicinal Uses

Antibacterial, antifungal, antitumor, antiviral, and anti-HIV activities of purine analogs have been reported. Some of the most popular medicines in the purine category include caffeine (a CNS stimulation drug), 6-mercaptopurine (an anti-cancer drug), and azithromycin. The antibiotic tubercidin (anticancer) contains an isostere of purine such as sildenafil (erectile dysfunction), allopurinol (anti-gout), and tubercidin (erectile dysfunction).


Get subject wise printable pdf notesView Here




is a prominent Pharmaceutical Quality Assurance expert, consultant and the founder of Pharmaguideline. With over 22 years of hands-on experience in cGMP-compliant manufacturing environments, he specializes in establishing validation protocols, sterile area controls and data integrity systems. Ankur routinely interprets international regulatory frameworks (including FDA, EMA and ICH guidelines) to help global pharmaceutical professionals ensure strict regulatory compliance and operational excellence. Connect with Ankur on LinkedIn. Need Help: Ask Question

No comments:

Post a Comment

Please don't spam. Comments having links would not be published.