Preparation and Standardization of 0.1 M Ceric Ammonium Sulphate : Pharmaceutical Guidelines

Preparation and Standardization of 0.1 M Ceric Ammonium Sulphate

Preparation and standardisation of 0.1 M Ceric Ammonium Sulphate solution using Arsenic Trioxide and Ferrroin Sulphate solution as indicator used in testing of pharmaceutical substances.

Ceric Ammonium Sulphate Solution Preparation

•  Dissolve 65 g of ceric ammonium sulphate, with the aid of gentle heat, in a mixture of 30 ml of sulphuric acid and 500 ml of water.
•  Cool, filter the solution, if turbid, and dilute to 1000 ml with water.
•  Standardize the solution in the following manner.

Ceric Ammonium Sulphate Solution Standardization

•  Weigh accurately about 0.2 g of arsenic trioxide, previously dried at 105° for 1 hour, and transferred to a 500 ml conical flask.
•  Wash down the inner walls of the flask with 25 ml of a 8.0 % w/v solution of sodium hydroxide, swirl to dissolve, add 100 ml of water and mix.
•  Add 30 ml of dilute sulphuric acid, 0.15 ml of osmic acid solution, 0.1 ml of ferrroin sulphate solution.
•  Titrate with the ceric ammonium sulphate solution until the pink color is changed to a very pale blue, adding the titrant slowly towards the end-point.
•  1 ml of 0.1 M ceric ammonium sulphate is equivalent to 0.004946 g of As2O3.
•  Calculate molarity of solution by following formula:
                           As2O3 in mg
M = ------------------------------------------------------
         Ceric Ammonium Sulphate in ml  x 4.946

Also see: Determination of Shelf Life of Solutions in Laboratory

Ankur Choudhary is India's first professional pharmaceutical blogger, author and founder of Pharmaceutical Guidelines, a widely-read pharmaceutical blog since 2008. Sign-up for the free email updates for your daily dose of pharmaceutical tips.
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