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Preparation and Standardization of 0.1 M Ceric Ammonium Sulphate

Preparation and standardisation of 0.1 M Ceric Ammonium Sulphate solution using Arsenic Trioxide and Ferrroin Sulphate solution as indicator used in testing of pharmaceutical substances.

Ceric Ammonium Sulphate Solution Preparation

  • Dissolve 65 g of ceric ammonium sulfate with the aid of gentle heat, in a mixture of 30 ml of sulphuric acid and 500 ml of water.
  • Cool, filter the solution, if turbid, and dilute to 1000 ml with water.
  • Standardize the solution in the following manner.

Ceric Ammonium Sulphate Solution Standardization

  • Weigh accurately about 0.2 g of arsenic trioxide, previously dried at 105° for 1 hour, and transferred to a 500 ml conical flask.
  • Wash down the inner walls of the flask with 25 ml of a 8.0 % w/v solution of sodium hydroxide, swirl to dissolve, add 100 ml of water and mix.
  • Add 30 ml of dilute sulphuric acid, 0.15 ml of osmic acid solution, 0.1 ml of ferroin sulfate solution.
  • Titrate with the ceric ammonium sulfate solution until the pink color is changed to a very pale blue, adding the titrant slowly towards the end-point.
  • 1 ml of 0.1 M ceric ammonium sulfate is equivalent to 0.004946 g of As2O3.
  • Calculate the molarity of the solution by the following formula:
                          As2O3 in mg
M = ------------------------------------------------------
      Ceric Ammonium Sulphate in ml x 4.946
Also see: Determination of Shelf Life of Solutions in Laboratory

Ankur Choudhary is India's first professional pharmaceutical blogger, author and founder of, a widely-read pharmaceutical blog since 2008. Sign-up for the free email updates for your daily dose of pharmaceutical tips.
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