Preparation and Standardization of 0.1 M Ceric Ammonium Sulphate : Pharmaceutical Guidelines

Editable Pharmaceutical Documents in MS-Word Format

View

8

Preparation and Standardization of 0.1 M Ceric Ammonium Sulphate

Preparation and standardisation of 0.1 M Ceric Ammonium Sulphate solution using Arsenic Trioxide and Ferrroin Sulphate solution as indicator used in testing of pharmaceutical substances.

Ceric Ammonium Sulphate Solution Preparation

  • Dissolve 65 g of ceric ammonium sulfate with the aid of gentle heat, in a mixture of 30 ml of sulphuric acid and 500 ml of water.
  • Cool, filter the solution, if turbid, and dilute to 1000 ml with water.
  • Standardize the solution in the following manner.

Ceric Ammonium Sulphate Solution Standardization

  • Weigh accurately about 0.2 g of arsenic trioxide, previously dried at 105° for 1 hour, and transferred to a 500 ml conical flask.
  • Wash down the inner walls of the flask with 25 ml of a 8.0 % w/v solution of sodium hydroxide, swirl to dissolve, add 100 ml of water and mix.
  • Add 30 ml of dilute sulphuric acid, 0.15 ml of osmic acid solution, 0.1 ml of ferroin sulfate solution.
  • Titrate with the ceric ammonium sulfate solution until the pink color is changed to a very pale blue, adding the titrant slowly towards the end-point.
  • 1 ml of 0.1 M ceric ammonium sulfate is equivalent to 0.004946 g of As2O3.
  • Calculate the molarity of the solution by the following formula:
                          As2O3 in mg
M = ------------------------------------------------------
      Ceric Ammonium Sulphate in ml x 4.946
Also see: Determination of Shelf Life of Solutions in Laboratory





Ankur Choudhary is India's first professional pharmaceutical blogger, author and founder of Pharmaceutical Guidelines, a widely-read pharmaceutical blog since 2008. Sign-up for the free email updates for your daily dose of pharmaceutical tips.
.moc.enilediugamrahp@ofni :liamENeed Help: Ask Question


Click Here

2 comments: Post Yours! Read Comment Policy ▼


Popular Categories

QA SOPs QC SOPs Micro SOPs HVAC Production SOPs Stores SOPs Checklists Maintenance SOPs HPLC Sterile GLP Validation Protocols Water System GDP Regulatory Maintenance Calibration

Follow Pharmaguideline


CURRENT JOBS

Show All ❭❭Jobs by PharmaJobs

WRITE A POWERFUL CV

Click Here



GET APP FOR NEWS UPDATES

Scan to Download

Android App
Android App

Recent Posts