Preparation and Standardization of 0.05 M Bromine : Pharmaceutical Guidelines

Editable Pharmaceutical Documents in MS-Word Format

View

8

Preparation and Standardization of 0.05 M Bromine

Preparation and standardisation of 0.05 M Bromine solution using Sodium Thiosulphate and 3 ml of Starch solution as indicator that is used in chemical analysis of pharmaceutical substances.

Bromine Solution Preparation

  • Dissolve 3 g of potassium bromate and 15 g of potassium bromide in sufficient water to produce 1000 ml.
  • Standardize the solution in the following manner.

Bromine Solution Standardization

  • Pipette 25.0 ml of the solution into a 500 ml iodine flask and dilute with 120 ml of water.
  • Add 5 ml of hydrochloric acid, insert the stopper in the flask and shake it gently.
  • Add 5 ml of potassium iodide solution, again insert the stopper and allow it to stand for 5 minutes in the dark. 
  • Titrate the liberated iodine with 0.1 M sodium thiosulphate using 3 ml of starch solution, added towards the end of the titration, as an indicator.
  • 1 ml of 0.1 M sodium thiosulphate is equivalent to 0.01598 g of Br2.
  • Store in dark amber-colored, glass-stoppered bottles.
Also see: Determination of Shelf Life of Solutions in Laboratory





Ankur Choudhary is India's first professional pharmaceutical blogger, author and founder of Pharmaceutical Guidelines, a widely-read pharmaceutical blog since 2008. Sign-up for the free email updates for your daily dose of pharmaceutical tips.
.moc.enilediugamrahp@ofni :liamENeed Help: Ask Question


Click Here

No comments: Read Comment Policy ▼

Post a Comment


Popular Categories

QA SOPs QC SOPs Micro SOPs HVAC Production SOPs Stores SOPs Checklists Maintenance SOPs HPLC Sterile GLP Validation Protocols Water System GDP Regulatory Maintenance Calibration Warning Letters

Follow Pharmaguideline


Discussion - Latest Topics

Show All ❭❭Pharmaguideline Forum

DOCUMENTS

PHARMACEUTICAL DOCUMENTS




Editable Pharmaceutical Documents in MS-Word Format. Ready to use SOPs, Protocols, Master Plans, Manuals and more...

View


adsbypg



GET APP FOR NEWS UPDATES

Scan to Download

Android App
Android App

Recent Posts