Preparation and Standardization of 0.004 M Benzethonium Chloride : Pharmaceutical Guidelines

Preparation and Standardization of 0.004 M Benzethonium Chloride

Preparation and standardisation of 0.004 M Benzethonium Chloride solution using Sodium Lauryl Sulphate and Dimethyl Yellow-Orcet Blue-B solution as indicator that is used in testing of pharmaceutical raw materials.

Benzethonium Chloride Solution Preparation 

•  Dissolve 1.792 g of benzethonium chloride, previously dried to constant weight at 105°, in sufficient water to produce 1000 ml.
•  Standardize the solution in the following manner.

Benzethonium Chloride Solution Standardization

•  Weigh accurately about 570 mg of Sodium lauryl sulphate, previously dried at about 105°C for about 1 hour.
•  Transfer it in a cleaned and dried 500 ml volumetric flask and add 300 ml of water with gentle stirring.
•  Make up the volume 500 ml with water. Mix solution thoroughly (Solution –A)
•  Take 20 ml of solution-A add 10 ml of water, 15 ml chloroform, 10 ml dilute sulphuric acid and add 1 ml dimethyl yellow-orcet blue-B solution as indicator.
•  Titrate with Benzothonium chloride solution

•  Calculate molarity of solution by following formula:

                                                                                   W (in gms) x 20
 Molarity of 0.004 M Benzothonium chloride =  ------------------------------
                                                                                  BR  x 0.28838 x 500

Also see: Determination of Shelf Life of Solutions in Laboratory

Ankur Choudhary is India's first professional pharmaceutical blogger, author and founder of Pharmaceutical Guidelines, a widely-read pharmaceutical blog since 2008. Sign-up for the free email updates for your daily dose of pharmaceutical tips.
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