Preparation and Standardization of 0.1 M Sodium Methoxide : Pharmaceutical Guidelines

Preparation and Standardization of 0.1 M Sodium Methoxide

Preparation and standardisation of 0.1 M Sodium Methoxide solution using Benzoic acid and Thymolphthalein solution as indicator that is used for pharmaceutical analysis.

Sodium Methoxide Solution Preparation

  • Cool 150 ml of anhydrous methanol in ice water and add, in small portions, about 2.5 g of freshly cut sodium. 
  • When the metal has dissolved, add sufficient toluene, previously dried over sodium wire to produce 1000 ml. 
  • Standardize the solution in the following manner immediately before use.

Sodium Methoxide Solution Standardization

  • Weigh accurately about 0.4 g of benzoic acid, dissolve in 80 ml of dimethylformamide.
  • Add 0.15 ml of thymolphthalein solution and titrate with sodium methoxide solution to a blue endpoint.
  • Protect the solution from atmospheric carbon dioxide throughout the titration. 
  • Perform a blank determination and make any necessary correction.
  • 1 ml of 0.1 M sodium methoxide is equivalent to 0.01221 g of C7H6O2.
  • Store protected from carbon dioxide and moisture.
  • Calculate the molarity of solution by the following formula:
                      C7H6O2 in mg
M = ------------------------------------------
      Sodium Methoxide in ml x 12.21
Also see: Determination of Shelf Life of Solutions in Laboratory

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Ankur Choudhary is India's first professional pharmaceutical blogger, author and founder of Pharmaceutical Guidelines, a widely-read pharmaceutical blog since 2008. Sign-up for the free email updates for your daily dose of pharmaceutical tips.
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