Preparation and Standardization of 0.5 M Sulphuric Acid : Pharmaceutical Guidelines

Preparation and Standardization of 0.5 M Sulphuric Acid

Preparation and standardisation of 0.5 M Sulphuric Acid using Sodium Carbonate and Methyl red solution as indicator used in pharmaceutical analysis.

Sulphuric Acid Solution Preparation

  • Add slowly, with stirring, 30 ml of Sulphuric acid to about 800 ml of purified water.
  • Makeup to 1000 ml with purified water.
  • Allow cooling at 25°C.

Sulphuric Acid Solution Standardization

  • Weigh accurately about 0.8 g of anhydrous Sodium Carbonate, previously heated at about 270°C for 1 hour.
  • Dissolve it in 100 ml of water and add 0.1 ml of methyl red solution.
  • Add the acid slowly from a burette, with constant stirring, until the solution becomes faintly pink.
  • Heat the solution to boiling, cool and continue the titration.
  • Heat again to boiling and titrate further as necessary until the faint pink color is no longer affected by continued boiling.
  • 1 ml of 0.5 M sulphuric acid is equivalent to 0.05299 g of Na2CO3.
  • Calculate the molarity of solution by the following formula:
           Na2CO3 in mg
M = -----------------------------
          H2SO4 in ml x 52.99
Also see: Determination of Shelf Life of Solutions in Laboratory





Ankur Choudhary is India's first professional pharmaceutical blogger, author and founder of Pharmaceutical Guidelines, a widely-read pharmaceutical blog since 2008. Sign-up for the free email updates for your daily dose of pharmaceutical tips.
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