Preparation and standardisation of 0.1 M Lead Nitrate solution using Disodium Edetate and Xylenol Orange mixture as indicator used in chemical analysis of pharmaceutical ingredients.
Lead Nitrate Solution Preparation
- Dissolve 33.12 g of lead nitrate in sufficient water to produce 1000 ml.
- Standardize the solution in the following manner.
Lead Nitrate Solution Standardization
- Pipette 50.0 ml of the solution into a flask.
- Add 50 mg of xylenol orange mixture and sufficient hexamine to produce a violet-pink color.
- Titrate with 0.1 M disodium edetate to a lemon yellow endpoint.
- 1 ml of 0.1 M disodium edetate is equivalent to 0.03312 g of Pb(N03)2.
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Dr. Ankur Choudhary is a prominent Pharmaceutical Quality Assurance expert, consultant and the founder of Pharmaguideline. With over 22 years of hands-on experience in cGMP-compliant manufacturing environments, he specializes in establishing validation protocols, sterile area controls and data integrity systems. Ankur routinely interprets international regulatory frameworks (including FDA, EMA and ICH guidelines) to help global pharmaceutical professionals ensure strict regulatory compliance and operational excellence. Connect with Ankur on LinkedIn. Need Help: Ask Question
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