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Preparation and Standardization of 0.1 M Lithium Methoxide

Preparation and standardisation 0.1 M Lithium Methoxide solution using Benzoic Acid and Quinaldine red solution as indicator that is used in pharmaceutical analysis.

Lithium Methoxide Solution Preparation

  • Dissolve in small portions 0.7 g of freshly cut lithium in 150 ml of anhydrous methanol, cooling the flask during the addition of the metal.
  • When the reaction is complete add sufficient toluene to produce 1000 ml.
  • If cloudiness or precipitation occurs, add sufficient anhydrous methanol to clarify the solution.
  • Standardise the solution immediately before use in the following manner.

Lithium Methoxide Solution Standardization

  • Weigh accurately about 0.25 g of benzoic acid, dissolved in 25 ml of dimethylformamide.
  • Titrate with lithium methoxide solution, using quinaldine red solution as the indicator and protecting the solution from atmospheric carbon dioxide throughout the titration.
  • Perform a blank determination and make any necessary correction.
  • 1 ml of 0.1 M lithium methoxide is equivalent to 0.01221 g of C7H6O2.
  • Calculate the molarity of solution by the following formula:
                    C7H6O2 in mg
M = ------------------------------------------
           Lithium Methoxide in ml x 12.21
Also see: Determination of Shelf Life of Solutions in Laboratory

Ankur Choudhary is India's first professional pharmaceutical blogger, author and founder of Pharmaceutical Guidelines, a widely-read pharmaceutical blog since 2008. Sign-up for the free email updates for your daily dose of pharmaceutical tips.
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