Assay of Calcium Carbonate : Pharmaceutical Guidelines

Assay of Calcium Carbonate

Learn how to determine the assay of Calcium Carbonate using Disodium Edetate, Sodium Hydroxide and calcon mixture as indicator.

Reagent required:

Dilute hydrochloric acid
0.05M Disodium Edetate
Sodium hydroxide solution
Calcon mixture


Weigh accurately about 0.1 g and dissolve in 3 ml of dilute hydrochloric acid and 10 ml of water. Boil for 10 minutes, cool, dilute to 50 ml with water. Titrate with 0.05M Disodium Edetate to within a few ml of the expected end-point, add 8 ml of sodium hydroxide solution and 0.1 g of calcon mixture as indicator and continue the titration until the colour of the solution changes from pink to a full blue colour. Each ml of 0.05M Disodium Edetate is equivalent to 0.005004 g of CaCO3.


                                  V x M x F        100
           % Assay  = -------------- x--------------
                                 0.05 x W        (100-LOD)
V  = Blank reading – Sample reading
M = Molarity of 0.05M Disodium Edetate
F  = Factor
W = Weight of sample

Ankur Choudhary is India's first professional pharmaceutical blogger, author and founder of Pharmaceutical Guidelines, a widely-read pharmaceutical blog since 2008. Sign-up for the free email updates for your daily dose of pharmaceutical tips.
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