Assay of Calcium Carbonate : Pharmaceutical Guidelines

Assay of Calcium Carbonate

Learn how to determine the assay of Calcium Carbonate using Disodium Edetate, Sodium Hydroxide and calcon mixture as indicator.

Reagent required

Dilute hydrochloric acid
0.05M Disodium Edetate
Sodium hydroxide solution
Calcon mixture


Weigh accurately about 0.1 g and dissolve in 3 ml of dilute hydrochloric acid and 10 ml of water. Boil for 10 minutes, cool, dilute to 50 ml with water. Titrate with 0.05M Disodium Edetate to within a few ml of the expected end-point, add 8 ml of sodium hydroxide solution and 0.1 g of calcon mixture as an indicator and continue the titration until the color of the solution changes from pink to a full blue color. Each ml of 0.05M Disodium Edetate is equivalent to 0.005004 g of CaCO3.
                    V x M x F          100
% Assay = -------------- x--------------
                    0.05 x W     (100-LOD)
V = Blank reading – Sample reading
M = Molarity of 0.05M Disodium Edetate
F = Factor
W = Weight of sample

Ankur Choudhary is India's first professional pharmaceutical blogger, author and founder of Pharmaceutical Guidelines, a widely-read pharmaceutical blog since 2008. Sign-up for the free email updates for your daily dose of pharmaceutical tips.
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