Test for Free Formaldehyde (Formaldehyde Content) : Pharmaceutical Guidelines

Test for Free Formaldehyde (Formaldehyde Content)

Learn hoe to determine the Formaldehyde Content by color development method.

Free Formaldehyde

Use Method A unless otherwise specified.

Method A

To 1.0 ml of a ten-fold dilution of the preparation under examination in a test-tube add 4.0 ml of water and 5.0 ml of acetylacetone reagent. Warm in a water-bath at 40° and allow to stand for 40 minutes. The solution is not more intensely colored than a reference solution prepared at the same time and in the same manner using 1.0 ml of a solution containing 0.002 percent w/v of formaldehyde, CH2O, in place of the dilution of the preparation. The comparison should be made examining the tubes down their vertical axes.

Method B

To 1.0 ml of ten-fold dilution of the preparation under examination in a test-tube add 2.0 ml of water, 1.0 ml of a 1 percent w/v solution of phenylhydrazine hydrochloride, 0.5 ml of a 5 percent w/v solution of potassium ferricyanide and 1.0 ml of hydrochloric acid and allow to stand for 15 minutes. The solution is not more intensely colored than a reference solution prepared at the same time and in the same manner using 1.0 ml of a solution containing 0.002 percent w/v of formaldehyde, CH2O, in place of the dilution of the preparation.
The comparison should be made examining the tubes down their vertical axes.

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Ankur Choudhary is India's first professional pharmaceutical blogger, author and founder of Pharmaceutical Guidelines, a widely-read pharmaceutical blog since 2008. Sign-up for the free email updates for your daily dose of pharmaceutical tips.
.moc.enilediugamrahp@ofni :liamENeed Help: Ask Question


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2 comments: Post Yours! Read Comment Policy ▼

  1. Hi Ankur,
    Could you please suggest if I have to conduct the test on a textile substrate then how do I perform it ?
    Awaiting for your reply.
    Regards,
    Pushkar

    ReplyDelete
  2. @Pushkar You can use above method to test formaldehyde.

    ReplyDelete


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