SOP for Cleaning of Colloidal Mill : Pharmaceutical Guidelines

SOP for Cleaning of Colloidal Mill

Standard operating procedure to clean the Colloidal Mill.


To lay down the cleaning procedure for Colloidal Mill.

2.0 SCOPE:

This SCP shall be applicable for Colloidal Mill used in Coating area in Production department.


3.1 Execution :Operator
3.2 Checking :Pharmacist and Above




5.1 Put “OFF” the electrical supply and cover all electrical parts with poly bag.
5.2 Feed 10 liter potable water to the hopper. Recirculate the potable water for 5- 6 minutes and adjust the knob on the outlet nozzle, discharge the potable water in S.S. vessel.
5.3 Remove the hopper and rotor.
5.4 Wipe out the residue using lint free cloth.
5.5 Clean the outer surface and base of the Mill with 10 liter Potable water and 2.5 % “Teepol” solution at least two times till the residue is washed off and rinse with 10 liter potable water.
5.6 Clean all the removed contact parts with 10 liter Potable water and 2.5 % “Teepol” solution.
5.7 Clean thoroughly with 10 liter Potable water to remove the detergent completely.
5.8 Apply 10 liter hot water to the removable parts thoroughly.
5.9 Finally rinse all the parts with about 20 liter purified water.
5.10 Wipe the parts with clean dry lint free cloth and then with 70 % v/v solution of Isopropyl Alcohol (IPA) and allow parts to dry.
5.11 Assemble the machine. Cover the hopper & delivery chute with polythene bags.
5.12 Affix “Cleaned” label and fill the “Equipment Log Book”.
5.13 Re-cleaned if not used within 72 hours.


SCP :Standard Cleaning Procedure
IPA :Isopropyl Alcohol

Ankur Choudhary is India's first professional pharmaceutical blogger, author and founder of Pharmaceutical Guidelines, a widely-read pharmaceutical blog since 2008. Sign-up for the free email updates for your daily dose of pharmaceutical tips.
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