SAR of Phenothiazines- Promazine hydrochloride, Chlorpromazine hydrochloride, Triflupromazine, Thioridazine hydrochloride, Piperacetazine hydrochloride, Prochlorperazine maleate, Trifluoperazine hydrochloride : Pharmaguideline -->

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SAR of Phenothiazines- Promazine hydrochloride, Chlorpromazine hydrochloride, Triflupromazine, Thioridazine hydrochloride, Piperacetazine hydrochloride, Prochlorperazine maleate, Trifluoperazine hydrochloride

Promazine hydrochloride is a phenothiazine derivative with antipsychotic and sedative properties.

Promazine hydrochloride

Promazine hydrochloride is a phenothiazine derivative with antipsychotic and sedative properties.

Mechanism of action:
Promazine hydrochloride inhibits the enzyme monoamine oxidase (MAO), responsible for the breakdown of neurotransmitters like serotonin and dopamine.

By inhibiting MAO, phenothiazines can prolong the action of these neurotransmitters, leading to their accumulation in the brain.

This property accounts for many of the side effects associated with phenothiazine use, including drowsiness, weight gain, and dry mouth.

Additionally, promazine hydrochloride has anticholinergic activity, meaning it can block the action of the neurotransmitter acetylcholine.

SAR of Promazine hydrochloride:
The structure of promazine hydrochloride is relatively simple, consisting of a benzene ring joined to a nitrogen-containing ring. This structure is similar in many ways to that of other antipsychotics and dopamine antagonists, suggesting that SAR analysis may be useful in predicting the activity of these compounds.

Chlorpromazine hydrochloride

Chlorpromazine hydrochloride is a phenothiazine derivative with antipsychotic and sedative properties.

Mechanism of action:
Chlorpromazine hydrochloride inhibits the enzyme monoamine oxidase (MAO), responsible for the breakdown of neurotransmitters like serotonin and dopamine.

By inhibiting MAO, phenothiazines can prolong the action of these neurotransmitters, leading to their accumulation in the brain.

Additionally, chlorpromazine hydrochloride has anticholinergic activity, meaning it can block the movement of the neurotransmitter acetylcholine.

SAR of Chlorpromazine hydrochloride:
Chlorpromazine hydrochloride is a dopamine antagonist that has been used in the treatment of schizophrenia and other psychiatric disorders. The structure of chlorpromazine hydrochloride is similar to that of promazine hydrochloride, consisting of a benzene ring joined to a nitrogen-containing ring.

This structure suggests that chlorpromazine hydrochloride and promazine hydrochloride may have similar SARs, as they share common features such as the presence of a nitrogen atom. One potential difference between the two compounds is that chlorpromazine hydrochloride contains an additional chlorine atom, which may change its activity in some way compared to promazine hydrochloride. More research is needed to fully understand the SAR of chlorpromazine hydrochloride and how it may differ from that of promazine hydrochloride.

Triflupromazine:

Triflupromazine is a phenothiazine derivative with antipsychotic and sedative properties.

Mechanism of action:
Triflupromazine inhibits the enzyme monoamine oxidase (MAO), responsible for the breakdown of neurotransmitters like serotonin and dopamine.

By inhibiting MAO, phenothiazines can prolong the action of these neurotransmitters, leading to their accumulation in the brain.

Additionally, triflupromazine has anticholinergic activity, meaning it can block the movement of the neurotransmitter acetylcholine.

SAR of Triflupromazine:
Triflupromazine is also a dopamine antagonist that has been used in the treatment of Like promazine hydrochloride and chlorpromazine hydrochloride, triflupromazine contains a benzene ring joined to a nitrogen-containing ring. Unlike these other compounds, however, triflupromazine also contains a fluorine atom. This fluorine atom may interact with the benzene ring in some way that alters the activity of the compound.

Thioridazine hydrochloride:

Thioridazine hydrochloride is a phenothiazine derivative with antipsychotic and sedative properties. It is used to treat schizophrenia and other mental disorders.




Mechanism of action:
Thioridazine hydrochloride inhibits the enzyme monoamine oxidase (MAO), responsible for the breakdown of neurotransmitters like serotonin and dopamine.

By inhibiting MAO, phenothiazines can prolong the action of these neurotransmitters, leading to their accumulation in the brain.

Additionally, thioridazine hydrochloride has anticholinergic activity, meaning it can block the movement of the neurotransmitter acetylcholine.

SAR of Thioridazine hydrochloride:
Like promazine, chlorpromazine, and triflupromazine, thioridazine contains a benzene ring joined to a nitrogen-containing ring. Unlike these other compounds, however, thioridazine also contains an oxygen atom as well as a sulfur atom.

Piperacetazine hydrochloride:

Piperacetazine hydrochloride is a phenothiazine derivative with antipsychotic and sedative properties.

Mechanism of action:
Piperacetazine hydrochloride inhibits the enzyme monoamine oxidase (MAO), responsible for the breakdown of neurotransmitters like serotonin and dopamine.

By inhibiting MAO, phenothiazines can prolong the action of these neurotransmitters, leading to their accumulation in the brain.

Additionally, piperacetazine hydrochloride has anticholinergic activity, meaning it can block the movement of the neurotransmitter acetylcholine.

SAR of Piperacetazine hydrochloride:
Piperacetazine hydrochloride is structurally similar to promazine hydrochloride, chlorpromazine hydrochloride, and triflupromazine, as it contains a benzene ring joined to a nitrogen-containing ring.

One potential difference between piperacetazine and these other compounds is the presence of an additional oxygen atom in piperacetazine's structure. This oxygen atom may interact with the benzene ring in some way that alters the activity of the compound.

Prochlorperazine maleate:

Prochlorperazine maleate is a phenothiazine derivative with antipsychotic and sedative properties.

Mechanism of action:
Prochlorperazine maleate inhibits the enzyme monoamine oxidase (MAO), responsible for the breakdown of neurotransmitters like serotonin and dopamine.

By inhibiting MAO, phenothiazines can prolong the action of these neurotransmitters, leading to their accumulation in the brain.

Additionally, prochlorperazine maleate has antidopaminergic activity, meaning it blocks the action of dopamine.

SAR of Prochlorperazine maleate:
Prochlorperazine maleate is structurally similar to promazine hydrochloride, chlorpromazine hydrochloride, triflupromazine, and piperacetazine hydrochloride, as it contains a benzene ring joined to a nitrogen-containing ring.

One potential difference between prochlorperazine and these other compounds is the presence of a carbon atom in prochlorperazine's structure. This carbon atom may interact with the benzene ring in some way that alters the activity of the compound.

Trifluoperazine hydrochloride:

Trifluoperazine hydrochloride is a phenothiazine derivative with antipsychotic and sedative properties.

Mechanism of action:
Trifluoperazine hydrochloride inhibits the enzyme monoamine oxidase (MAO), responsible for the breakdown of neurotransmitters like serotonin and dopamine.

By inhibiting MAO, phenothiazines can prolong the action of these neurotransmitters, leading to their accumulation in the brain.

Additionally, trifluoperazine hydrochloride has antidopaminergic activity, meaning it blocks the action of dopamine.

SAR of Trifluoperazine hydrochloride:
Trifluoperazine hydrochloride is a dopamine antagonist that has been used in the treatment of schizophrenia and other psychiatric disorders. It is structurally similar to promazine hydrochloride, chlorpromazine hydrochloride, triflupromazine, piperacetazine hydrochloride, and prochlorperazine maleate, as it contains a benzene ring joined to a nitrogen-containing ring.

One potential difference between trifluoperazine and these other compounds is the presence of an additional fluorine atom in trifluoperazine's structure. This fluorine atom may interact with the benzene ring in some way that alters the activity of the compound.
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Ankur Choudhary is India's first professional pharmaceutical blogger, author and founder of Pharmaceutical Guidelines, a widely-read pharmaceutical blog since 2008. Sign-up for the free email updates for your daily dose of pharmaceutical tips.
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