Pharmaceutical dosage forms can be defined by their appearance as much as (if not more than) their formulation. The shape of a dosage form has a significant impact on its function, manufacturability and acceptance by patients.
Showing posts with label Non-sterile. Show all posts
Sweetening Agents for Oral Pharmaceutical Suspensions
The taste of the medication has a significant impact on the ability of patients to follow their treatment regiment when taking oral pharmaceutical suspension. This is especially true for children, the elderly and those with sensitivity to tastes. Many active pharmaceutical ingredients (APIs) have a naturally occurring bitter or unpleasant taste that can negatively affect the medicine taking abili…
How to Strengthen Microbiological Control of Non-Sterile Pharmaceuticals
Microbiological quality of pharmaceutical products is essential for patient safety and product stability. As we know, the sterile products are manufactured in a sterile environment, but non-sterile products like tablets, capsules and liquid pharmaceutical products are manufactured in non-sterile manufacturing area.
Importance of Blend Uniformity in Manufacturing Process
Blend uniformity is an important factor in pharmaceutical manufacturing. A poor uniformity of the blend can cause the rejection of the product that can lead to the loss of revenue.
Manufacturing of Tablets by Direct Compression Method
In the past years, the processing of drugs was mostly achieved through wet granulation or related unit operations. Progressively, other methods emerged that revolutionalized and gradually replaced the old tablet manufacturing methods. Amongst the new techniques, the direct compression method uses the most advanced technology.
Granulation Process in Pharmaceutical Manufacturing
Granulation is a process of producing granules generally. In pharmaceutical manufacturing, granulation process implies the techniques that are, used to combine powdered particles to form relatively bigger ones called granules. This process is used for commercial production of tablets.
Pharmaceutical Formulation Questions and Answers
For questions 1-6, answer with true or false
1. In the compaction of tablets, the first step to occur as the punch enters the die is elastic Deformation. 2. Although direct compression eliminates exposure of a drug to heat and moisture, it does not Significantly reduce the number of steps involved in tablet manufacture. 3. The major problem in producing tablets of highly potent drugs (low dose) by d…
1. In the compaction of tablets, the first step to occur as the punch enters the die is elastic Deformation. 2. Although direct compression eliminates exposure of a drug to heat and moisture, it does not Significantly reduce the number of steps involved in tablet manufacture. 3. The major problem in producing tablets of highly potent drugs (low dose) by d…
Types and Size of Capsules
Capsules are gelatin containers that contain medicines. These are common pharmaceutical dosage forms those are easy to manufacture. Capsules do not require any complex formulation to manufacture.
Solid Pharmaceutical Dosage Forms - Tablets
IntroductionTablets are solid dosage forms each containing a unit dose of one or more active ingredients. They are intended for oral administration. Some tablets are swallowed whole or after being chewed, some are dissolved or dispersed in water before administration and some are retained in the mouth where the active ingredient is liberated.
Because of their composition, the method of manufactur…
Because of their composition, the method of manufactur…
Pharmaceutical Excipients and Their Suggested Quantity
Following are some of the most common excipients and their suggested use levels in pharmaceutical preparations.
1. Binders: • Polyvinylpyrrolidone (PVP) : 0.5-4% • Pregelatinized starch : 5-10% (wet), 5-20% (direct) • Starch paste : 5-25% w/w • Microcrystalline cellulose : 5-25% (wet), 5-25% (direct) • Sucrose : 50-70% solution • Hydroxypropyl cellulose : 4-6% • Ethyl…
1. Binders: • Polyvinylpyrrolidone (PVP) : 0.5-4% • Pregelatinized starch : 5-10% (wet), 5-20% (direct) • Starch paste : 5-25% w/w • Microcrystalline cellulose : 5-25% (wet), 5-25% (direct) • Sucrose : 50-70% solution • Hydroxypropyl cellulose : 4-6% • Ethyl…
