Preparation and standardisation of 0.1 M Ethanolic Potassium Hydroxide using Hydrochloric acid and Phenolphthalein solution used for pharmaceutical analysis.
Ethanolic Potassium Hydroxide Solution Preparation
- Dissolve about 6 g of potassium hydroxide in 5 ml of water.
- Add sufficient aldehyde-free ethanol (95 %) to produce 1000 ml.
- Allow the solution to stand in a tightly-stoppered bottle for 24 hours.
- Then quickly decant the clear supernatant liquid into a suitable, tightly-closed container.
- Standardize the solution in the following manner.
Ethanolic Potassium Hydroxide Solution Standardization
- Pipette 20.0 ml of 0.1 M hydrochloric acid into a flask.
- Dilute with 50 ml of water and add 0.1 ml of phenolphthalein solution.
- Titrate with the ethanolic potassium hydroxide solution until a permanent pale pink color is produced.
- Store protected from light and moisture.
- 1 ml of 0.1 M hydrochloric acid is equivalent to 0.00561 g of KOH.
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Dr. Ankur Choudhary is a prominent Pharmaceutical Quality Assurance expert, consultant and the founder of Pharmaguideline. With over 22 years of hands-on experience in cGMP-compliant manufacturing environments, he specializes in establishing validation protocols, sterile area controls and data integrity systems. Ankur routinely interprets international regulatory frameworks (including FDA, EMA and ICH guidelines) to help global pharmaceutical professionals ensure strict regulatory compliance and operational excellence. Connect with Ankur on LinkedIn. Need Help: Ask Question
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