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Preparation and Standardization of 0.5 M Sulphuric Acid

Preparation and standardisation of 0.5 M Sulphuric Acid using Sodium Carbonate and Methyl red solution as indicator used in pharmaceutical analysis.

Sulphuric Acid Solution Preparation:

•  Add slowly, with stirring, 30 ml of Sulphuric acid to about 800 ml of purified water.
•  Make up to 1000 ml with purified water.
•  Allow to cool 25°C.

Sulphuric Acid Solution Standardization:

•  Weigh accurately about 0.8 g of anhydrous Sodium Carbonate, previously heated at about 270°C for 1 hour.
•  Dissolve it in 100 ml of water and add 0.1 ml of methyl red solution.
•  Add the acid slowly from a burette, with constant stirring, until the solution becomes faintly pink.
•  Heat the solution to boiling, cool and continue the titration.
•  Heat again to boiling and titrate further as necessary until the faint pink colour is no longer affected by continued boiling.
•  1 ml of 0.5 M sulphuric acid is equivalent to 0.05299 g of Na2CO3.
•  Calculate molarity of solution by following formula:
              Na2CO3 in mg
M = -----------------------------
         H2SO4 in ml  x 52.99

Also see: Determination of Shelf Life of Solutions in Laboratory

Ankur Choudhary is India's first professional pharmaceutical blogger, author and founder of Pharmaceutical Guidelines, a widely-read pharmaceutical blog since 2008. Sign-up for the free email updates for your daily dose of pharmaceutical tips.
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