Preparation and Standardization of 0.1 M Sodium Nitrite : Pharmaceutical Guidelines

Preparation and Standardization of 0.1 M Sodium Nitrite

Preparation and standardisation of 0.1 M Sodium Nitrite using Sulphanilamide used or pharmaceutical analysis of raw material.

Sodium Nitrite Solution Preparation:

•  Dissolve 7.5 g of sodium nitrite in 800 ml of purified water.
•  Make up with purified water to produce 1000 ml.
•  Standardize the solution in the following manner.

Sodium Nitrite Solution Standardization:

•  Dissolve 0.3 g of Sulphanilamide in 50 ml of 2 M hydrochloric acid.
•  Add 3 g of potassium bromide, cool in ice and titrate with the sodium nitrite solution determining the end-point potentiometrically.
•  1 ml of 0.1 M sodium nitrite is equivalent to 0.01722 g of Sulphanilamide.
•  Calculate molarity of solution by following formula:

           Sulphanilamide in mg
M = -------------------------------
         NaNO2 in ml  x 17.22

Also see: Determination of Shelf Life of Solutions in Laboratory

Ankur Choudhary is India's first professional pharmaceutical blogger, author and founder of Pharmaceutical Guidelines, a widely-read pharmaceutical blog since 2008. Sign-up for the free email updates for your daily dose of pharmaceutical tips.
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