SOP for Oven of Loss on Drying : Pharmaceutical Guidelines

SOP for Oven of Loss on Drying

Standard operating procedure of drying oven used to determine the loss on drying.

1.0 OBJECTIVE

To lay down the procedure for operation of L.O.D. oven.

2.0 SCOPE

This SOP shall be applicable to Quality Control Dept.

3.0 RESPONSIBILITY

Supervisor Quality Control

4.0 ACCOUNTABILITY

Sr. Manager Quality Assurance

5.0 PROCEDURE

5.1 Tightly close the door of the oven.
5.2 Switch on the instrument.
5.3 Set desired temperature using temperature control knob.
5.4 Allow the instrument to reach the desired temperature.
5.5 Switch off the instrument and place substance to be dried into the oven.
5.6 Close the door tightly & switch on the instrument.
5.7 Allow substance to be dried in the desired temperature for the specified time period.
5.8 Switch off the oven.
5.9 Remove substance & place in a desiccator to attain Room Temperature before weighing.
5.10 If drying in the vacuum is required, after step (5.6), connect a vacuum pump to vacuum nozzle & allow the desired vacuum to be created, then close the vacuum knob tightly and proceed to step (5.7), maintaining the vacuum throughout the drying process.
Related: Difference Between Water (Moisture) Content and Loss on Drying (LOD)

6.0 ABBREVIATIONS

6.1 SOP: Standard Operating Procedure
6.2 Dept.: Department

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Ankur Choudhary is India's first professional pharmaceutical blogger, author and founder of Pharmaceutical Guidelines, a widely-read pharmaceutical blog since 2008. Sign-up for the free email updates for your daily dose of pharmaceutical tips.
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